Faculty of Education, University of Ljubljana, Krdeljeva ploščad 16, 1000 Ljubljana, Slovenia.
Department of Nephrology, University Medical Centre Ljubljana, Zaloška cesta 2, 1000 Ljubljana, Slovenia.
Int J Environ Res Public Health. 2021 Feb 18;18(4):1978. doi: 10.3390/ijerph18041978.
Hemodialysis (HD) patients have lower functional abilities compared to healthy people, and this is associated with lower physical activity in everyday life. This may affect their quality of life, but research on this topic is limited. Therefore, the present study aimed to determine the relationship between habitual physical activity and quality of life in HD patients and healthy controls. Ninety-three HD patients and 140 controls participated in the study. Quality of life was assessed using a 36-item medical outcomes study short-form health survey (SF-36). Human Activity Profile (HAP) was used to assess habitual physical activity. The adjusted activity score (AAS) from HAP, age, gender, fat tissue index (FTI), lean tissue index (LTI), and Davies comorbidity score were analyzed as possible predictors of the Physical Component Summary (PCS) of the SF-36. Three sequential linear models were used to model PCS. In Model 1, PCS was regressed by gender and age; in Model 2 the LTI, FTI, and Davies comorbidity scores were added. Model 3 also included AAS. After controlling for age and gender (Model 1: = 0.056), LTI, FTI, and Davies comorbidity score effects (Model 2: = 0.181), the AAS accounted for 32% of the variation in PCS of HD patients (Model 3: < 0.001). Consequently, the PCS of HD patients would increase by 0.431 points if the AAS increased by one point. However, in healthy controls, AAS had a lower impact than in the HD sample (B = 0.359 vs. 0.431), while the corresponding effects of age and gender (Model 1: < 0.001), LTI, FTI, and Davies comorbidity score (Model 2: < 0.001) were adjusted for. The proportion of variation in PCS attributed to AAS was 14.9% (Model 3: < 0.001). The current study results showed that physical activity in everyday life as measured by the HAP questionnaire is associated to a higher degree with the quality of life of HD patients than in healthy subjects. Routine physical activity programs are therefore highly justified, and the nephrology community should play a leading role in this effort.
血液透析（HD）患者的功能能力低于健康人群，这与日常生活中的体力活动较少有关。这可能会影响他们的生活质量，但关于这个主题的研究有限。因此，本研究旨在确定 HD 患者和健康对照组中习惯性体力活动与生活质量之间的关系。93 名 HD 患者和 140 名对照者参与了这项研究。使用 36 项医疗结局研究短表健康调查（SF-36）评估生活质量。使用人类活动概况（HAP）评估习惯性体力活动。从 HAP 分析调整后的活动评分（AAS）、年龄、性别、脂肪组织指数（FTI）、瘦组织指数（LTI）和戴维斯合并症评分，作为 SF-36 身体成分综合评分（PCS）的可能预测因子。使用三个连续的线性模型来对 PCS 进行建模。在模型 1 中，PCS 由性别和年龄回归；在模型 2 中，加入 LTI、FTI 和戴维斯合并症评分。模型 3 还包括 AAS。在控制年龄和性别后（模型 1： = 0.056），LTI、FTI 和戴维斯合并症评分的影响（模型 2： = 0.181），AAS 解释了 HD 患者 PCS 变异的 32%（模型 3： < 0.001）。因此，如果 AAS 增加 1 分，HD 患者的 PCS 将增加 0.431 分。然而，在健康对照组中，AAS 的影响低于 HD 样本（B = 0.359 与 0.431），而年龄和性别（模型 1： < 0.001）、LTI、FTI 和戴维斯合并症评分（模型 2： < 0.001）的相应影响进行了调整。AAS 对 PCS 变异的解释比例为 14.9%（模型 3： < 0.001）。本研究结果表明，HAP 问卷测量的日常生活中的体力活动与 HD 患者的生活质量相关性更高，而与健康受试者的相关性较低。因此，常规体力活动方案具有高度合理性，肾脏病学领域应在这方面发挥主导作用。
