微小RNA与埃博拉病毒相互作用的综述

A Review of the Interaction between miRNAs and Ebola Virus.

作者信息

Kakavandi Ehsan, Yavarian Jila, Farzanehpour Mahdieh, Shayestehpour Mohammad

机构信息

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

出版信息

Int J Mol Cell Med. 2024;13(2):210-219. doi: 10.22088/IJMCM.BUMS.13.2.210.

DOI:10.22088/IJMCM.BUMS.13.2.210

PMID:39184819

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11344561/

Abstract

Ebola virus (EBOV) is a life-threatening and virulent pathogen that kills approximately 90 percent of infected individuals. Nowadays, microRNAs (miRNAs) have become a promising option for more efficient screening, diagnosis, monitoring, and therapy of numerous diseases such as cancer, stroke, Alzheimer's, and viral infections. Recent studies have revealed the role of EBOV and host-encoded miRNAs in Ebola virus disease (EVD), opening an avenue for developing novel drugs against EVD and diagnostic panels for EBOV infection. EBOV-encoded miRNAs such as miR-VP-3p and miR-1-5p and anti-EBOV host cell miRNAs such as has-miR-150-3p, has-miR-103b and has-miR-145-3p might be a possible diagnostic biomarker or druggable targets. This paper highlights the importance of viral and cellular miRNAs in EBOV infection and EVD.

摘要

埃博拉病毒（EBOV）是一种危及生命的高致病性病原体，约90%的感染者会死亡。如今，微小RNA（miRNA）已成为更高效筛查、诊断、监测和治疗多种疾病（如癌症、中风、阿尔茨海默病和病毒感染）的一个有前景的选择。最近的研究揭示了EBOV和宿主编码的miRNA在埃博拉病毒病（EVD）中的作用，为开发针对EVD的新型药物和EBOV感染的诊断方法开辟了道路。EBOV编码的miRNA，如miR-VP-3p和miR-1-5p，以及抗EBOV宿主细胞miRNA，如has-miR-150-3p、has-miR-103b和has-miR-145-3p，可能是潜在的诊断生物标志物或可成药靶点。本文强调了病毒和细胞miRNA在EBOV感染和EVD中的重要性。