使用两种双膦酸盐治疗佩吉特病的临床经验。
Clinical experience with the use of two diphosphonates in the treatment of Paget's disease.
作者信息
Dewis P, Prasad B K, Anderson D C, Willets S
出版信息
Ann Rheum Dis. 1985 Jan;44(1):34-8. doi: 10.1136/ard.44.1.34.
Abstract
The effects of EHDP (20 mg/kd/day) and APD (4.5 mg/kg/day) given for three months to patients with severe symptomatic Paget's disease have been compared in an open trial of 17 patients. Both drugs were equally effective in producing a prompt reduction in pair scores, urine hydroxyproline, and serum alkaline phosphatase levels. The remission was maintained for a variable period after stopping treatment. Both drugs were well tolerated, and a one-month course of either drug was not effective. Comparison with published responses from previous studies indicates that EHDP given at this dose as a relatively short course is more effective than a lower dose for a longer period of time; the present study does not suggest that APD has significant advantages.
摘要
在一项针对17例严重症状性佩吉特病患者的开放性试验中，比较了给予依替膦酸二钠（EHDP，20毫克/千克/天）和阿仑膦酸钠（APD，4.5毫克/千克/天）三个月的效果。两种药物在迅速降低疼痛评分、尿羟脯氨酸和血清碱性磷酸酶水平方面同样有效。停药后缓解期持续时间不一。两种药物耐受性良好，单药一个月疗程无效。与先前研究发表的反应相比表明，以该剂量相对短期给予依替膦酸二钠比长时间给予较低剂量更有效；本研究未表明阿仑膦酸钠有显著优势。
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本文引用的文献
1
Chemistry, physiology, and therapeutic applications of calcitonin.
Arthritis Rheum. 1980 Oct;23(10):1139-47. doi: 10.1002/art.1780231011.
2
Clinical and biological effects of low doses of (3 amino-1 hydroxypropylidene)-1,1-bisphosphonate (APD) in Paget's disease of bone.低剂量（3-氨基-1-羟基亚丙基）-1,1-二膦酸盐（APD）对骨Paget病的临床和生物学效应
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3
Long-term therapy of Paget's disease of bone with EHDP.用依替膦酸二钠对骨佩吉特病进行长期治疗。
Arthritis Rheum. 1980 Oct;23(10):1177-84. doi: 10.1002/art.1780231016.
4
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5
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