Siris E S, Canfield R E, Jacobs T P, Baquiran D C
Arthritis Rheum. 1980 Oct;23(10):1177-84. doi: 10.1002/art.1780231016.
Forty patients with Paget's disease of bone were treated with intermittent courses of the diphosphonate, EHDP. Seven individuals had prolonged remissions after their initial course of therapy, nineteen responded to retreatment with 5 mg/kg of EHDP for 6 months of each year, while 14 patients required cycles of 20 mg/kg for 1 month of every 4. Improvement was indicated by alleviation of symptoms and reduction in serum alkaline phosphatase and urinary hydroxyproline. Data suggesting a possible role for parathyroid hormone in the expression of Paget's disease are also discussed.
40例骨Paget病患者接受了二膦酸盐EHDP的间歇疗程治疗。7例患者在初始治疗疗程后获得了长期缓解，19例患者对每年以5mg/kg的剂量给予EHDP、为期6个月的再治疗有反应，而14例患者需要每4个月以20mg/kg的剂量治疗1个月的疗程。症状减轻、血清碱性磷酸酶和尿羟脯氨酸降低表明病情有所改善。文中还讨论了提示甲状旁腺激素在Paget病表现中可能起作用的数据。
