General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China.
Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
Front Immunol. 2024 Aug 9;15:1404615. doi: 10.3389/fimmu.2024.1404615. eCollection 2024.
Chronic obstructive pulmonary disease (COPD) is a common respiratory disease characterized by irreversible progressive airflow limitation, often manifested by persistent cough, sputum production and other respiratory symptoms that pose a serious threat to human health and affect the quality of life of patients. The disease is associated with chronic inflammation, which is associated with the onset and progression of COPD, but anti-inflammatory therapy is not first-line treatment. Inflammation has multiple manifestations and phenotypes, and this heterogeneity reveals different patterns of inflammation, making treatment difficult. This paper aims to explore the direction of more effective anti-inflammatory treatment by analyzing the nature of inflammation and the molecular mechanism of disease occurrence and development in COPD patients, and to provide new ideas for the treatment of COPD patients.
慢性阻塞性肺疾病(COPD)是一种常见的呼吸系统疾病,其特征为不可逆转的进行性气流受限,常表现为持续咳嗽、咳痰等呼吸道症状,严重威胁人类健康,影响患者生活质量。该疾病与慢性炎症相关,炎症的发生和发展与 COPD 有关,但抗炎治疗并非一线治疗方法。炎症具有多种表现和表型,这种异质性揭示了不同的炎症模式,使治疗变得困难。本文旨在通过分析 COPD 患者炎症的本质和疾病发生发展的分子机制,探索更有效的抗炎治疗方向,为 COPD 患者的治疗提供新的思路。