炎症性肠病中性功能障碍的患病率：系统评价与荟萃分析

Prevalence of Sexual Dysfunction in Inflammatory Bowel Disease: Systematic Review and Meta-analysis.

作者信息

Nardone Olga Maria, Calabrese Giulio, Bertin Luisa, Ford Alexander C, Castiglione Fabiana, Zingone Fabiana, Savarino Edoardo, Barberio Brigida

机构信息

Gastroenterology Unit, Department of Public Health, University of Naples Federico II, Naples, Italy.

Gastroenterology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

出版信息

J Crohns Colitis. 2025 Feb 4;19(2). doi: 10.1093/ecco-jcc/jjae133.

DOI:10.1093/ecco-jcc/jjae133

PMID:39185800

Abstract

BACKGROUND AND AIMS

Patients with inflammatory bowel disease (IBD) may experience symptoms of sexual dysfunction (SD). However, the magnitude of this problem remains uncertain. Therefore, we performed a systematic review and meta-analysis to assess the prevalence of SD in adult patients with IBD.

METHODS

MEDLINE, EMBASE, and EMBASE Classic (from inception to April 9, 2024) were searched to identify observational studies reporting the prevalence of SD in adult patients with IBD based on validated screening instruments. Data were extracted, and pooled prevalence (PP), odds ratios (ORs), and 95% confidence intervals (CIs) were calculated.

RESULTS

Of 1017 citations evaluated, 18 articles fulfilled the eligibility criteria, containing 2694 patients with IBD recruited from 13 different countries. The PP of SD in IBD patients was 50.6% (95% CI, 40.8%-60.5%; I2 = 96.3%) with an OR = 2.94 (95% CI, 1.99%-4.35%, I2 = 73.4) compared to healthy controls. When we considered ulcerative colitis (UC) or Crohn's disease (CD) separately, the PP of SD was 64.8% (95% CI, 45.1%-82.1%; I2 = 88.8%) in patients with UC and 58.3% (95% CI, 36.0%-79.0%; I2 = 95.3%) in patients with CD. In the subgroup analysis based on sex, the PP of SD was higher in females with IBD than in males (62.7% vs 34.0%; OR = 3.99, 95% CI, 2.80%-5.68%; I2 = 61.7%). Furthermore, the PP of SD was higher in patients with active disease than in patients with inactive disease (75.1% vs 34.2%; OR = 9.65, 95% CI, 1.02%-91.33%, I2 = 95.5%).

CONCLUSIONS

We demonstrated high prevalence of SD in IBD patients, especially in women. Encouraging gastroenterologists to screen for, and treat, these disorders with a holistic approach might improve quality of life of patients with IBD.

摘要

背景与目的

炎症性肠病（IBD）患者可能会出现性功能障碍（SD）症状。然而，这一问题的严重程度仍不确定。因此，我们进行了一项系统综述和荟萃分析，以评估成年IBD患者中SD的患病率。

方法

检索MEDLINE、EMBASE和EMBASE Classic（从创刊至2024年4月9日），以确定基于经验证的筛查工具报告成年IBD患者中SD患病率的观察性研究。提取数据，并计算合并患病率（PP）、比值比（OR）和95%置信区间（CI）。

结果

在评估的1017篇文献中，18篇文章符合纳入标准，包含从13个不同国家招募的2694例IBD患者。与健康对照相比，IBD患者中SD的PP为50.6%（95%CI，40.8%-60.5%；I²=96.3%），OR=2.94（95%CI，1.99%-4.35%，I²=73.4）。当我们分别考虑溃疡性结肠炎（UC）或克罗恩病（CD）时，UC患者中SD的PP为64.8%（95%CI，45.1%-82.1%；I²=88.8%），CD患者中为58.3%（95%CI，36.0%-79.0%；I²=95.3%）。在基于性别的亚组分析中，IBD女性患者中SD的PP高于男性（62.7%对34.0%；OR=3.99，95%CI，2.80%-5.68%；I²=61.7%）。此外，活动期疾病患者中SD的PP高于非活动期疾病患者（75.1%对34.2%；OR=9.65，95%CI，1.02%-91.33%，I²=95.5%）。