Department of Geriatrics and National Clincal Research Center for Geriatrics, West China Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, People's Republic of China.
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, People's Republic of China.
Int J Colorectal Dis. 2021 Sep;36(9):2027-2038. doi: 10.1007/s00384-021-03958-y. Epub 2021 May 29.
Sexual dysfunction (SD) is increasingly identified in patients with inflammatory bowel disease (IBD), but there are few systematic reviews and meta-analyses of the studies of SD in IBD patients. The purpose of the study is to further quantify the association between IBD and SD.
MEDLINE (OVID), EMBASE (OVID), and the Cochrane Library (OVID) were searched (until August 2020) to identify observational studies that reported the prevalence and risk factors of SD in IBD patients. Pooled prevalence, odds ratios (ORs), and 95% confidence intervals (95% CIs) were calculated.
Of the 945 citations evaluated, 18 studies (including 36,676 subjects) reporting the prevalence of SD in the IBD population were included for analysis. The overall pooled prevalence was 39% (95% CI 37-40%, P < 0.001). The prevalence of SD in women was 53% (95% CI 50-55%, P < 0.001), and it was 27% (95% CI 25-29%, P < 0.001) in men. The prevalence was higher in conjunction with operation (OR, 1.33, 95% CI 1.22-1.45, P < 0.001), depression (OR 6.14, 95% CI 3.51-10.76, P < 0.001), disease activity (OR 2.73, 95% CI 1.32-5.64, P = 0.007), comorbidities (OR 3.21, 95% CI 2.06-5.00, P < 0.001), age < 50 years (OR 3.85, 95% CI 2.41-6.14, P < 0.001), and the need for corticosteroids (OR 2.62, 95% CI 1.48-4.66, P = 0.001).
SD occurred frequently in the IBD population. Operation, depression, disease activity, comorbidities, age < 50 years, and the need for corticosteroids were risk factors for SD in IBD patients. SD screening might be recommended in IBD patients with the aforementioned factors.
性性功能障碍（SD）在炎症性肠病（IBD）患者中越来越多地被发现，但很少有系统评价和荟萃分析对 IBD 患者的 SD 进行研究。本研究的目的是进一步量化 IBD 与 SD 之间的关联。
检索 MEDLINE（OVID）、EMBASE（OVID）和 Cochrane 图书馆（OVID），以确定报告 IBD 患者 SD 患病率和危险因素的观察性研究。计算汇总患病率、比值比（ORs）和 95%置信区间（95%CI）。
在评估的 945 条引文中有 18 项研究（包括 36676 名受试者）报告了 IBD 人群中 SD 的患病率，用于分析。总体汇总患病率为 39%（95%CI 37-40%，P<0.001）。女性的 SD 患病率为 53%（95%CI 50-55%，P<0.001），男性为 27%（95%CI 25-29%，P<0.001）。手术（OR，1.33，95%CI 1.22-1.45，P<0.001）、抑郁（OR，6.14，95%CI 3.51-10.76，P<0.001）、疾病活动度（OR，2.73，95%CI 1.32-5.64，P=0.007）、合并症（OR，3.21，95%CI 2.06-5.00，P<0.001）、年龄<50 岁（OR，3.85，95%CI 2.41-6.14，P<0.001）和需要皮质类固醇（OR，2.62，95%CI 1.48-4.66，P=0.001）是 SD 的危险因素。
SD 在 IBD 人群中发生率较高。手术、抑郁、疾病活动度、合并症、年龄<50 岁和需要皮质类固醇是 IBD 患者 SD 的危险因素。建议对具有上述因素的 IBD 患者进行 SD 筛查。
