Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Indian J Ophthalmol. 2024 Sep 1;72(9):1308-1314. doi: 10.4103/IJO.IJO_3213_23. Epub 2024 Aug 23.
This study aimed to compare the safety, efficacy, and visual outcomes of 80-microns LASIK versus 100-microns LASIK in managing myopia and myopic astigmatism. The study was conducted at a tertiary care hospital in North India.
This was a prospective contralateral eye study that included patients with myopia and myopic astigmatism seeking refractive correction. The eligibility criteria included normal corneal topography, an epithelial thickness less than 60 microns, a calculated percentage tissue ablation (with 100-microns flap) less than 40%, a calculated residual stromal bed thickness (with 100-microns flap) more than 300 microns, and willingness to participate and follow up. Patients with glaucoma, cataracts, other visually disabling ocular pathologies, and a history of past ocular surgery were excluded. All patients underwent LASIK with 80-microns LASIK in one eye and 100-microns LASIK in the other eye. The patients were followed up for 6 months, and the results were analyzed.
The study included 216 eyes of 108 patients. The mean preoperative spherical equivalent in the 80-microns group and the 100-microns group was -3.53 ± 1.81 and -3.69 ± 1.32 diopters, respectively (P = 0.78). The mean 6 months decimal postoperative UCVA was 0.98 ± 0.13 in the 80-microns group and 0.97 ± 0.14 in the 100-microns group (P = 0.99). The postoperative change in the higher-order aberration profile was comparable in both groups (P = 0.78). The percentage tissue ablation was significantly lower in the 80-microns group (P = 0.002). The incidence of flap micro striae and OBL was higher in the 80-microns group, while neither of these had any visual implications.
The study concluded that 80-microns LASIK is an efficacious and safe alternative to 100-micron LASIK, especially useful in patients with higher myopia.
本研究旨在比较 80 微米 LASIK 与 100 微米 LASIK 在治疗近视和近视散光中的安全性、有效性和视觉效果。该研究在印度北部的一家三级保健医院进行。
这是一项前瞻性的对照眼研究，纳入了寻求屈光矫正的近视和近视散光患者。入选标准包括正常角膜地形，上皮厚度小于 60 微米，计算的组织消融百分比（用 100 微米瓣）小于 40%，计算的剩余基质床厚度（用 100 微米瓣）大于 300 微米，以及愿意参与和随访。排除青光眼、白内障、其他致盲性眼病变和既往眼手术史的患者。所有患者均接受 80 微米 LASIK 一只眼和 100 微米 LASIK 另一只眼治疗。患者随访 6 个月，分析结果。
该研究纳入了 108 例患者的 216 只眼。80 微米组和 100 微米组术前平均等效球镜分别为-3.53 ± 1.81 和-3.69 ± 1.32 屈光度（P = 0.78）。80 微米组和 100 微米组术后 6 个月十进制最佳矫正视力（UCVA）分别为 0.98 ± 0.13 和 0.97 ± 0.14（P = 0.99）。两组术后高阶像差谱的变化相似（P = 0.78）。80 微米组组织消融百分比明显较低（P = 0.002）。80 微米组瓣微条纹和 OBL 的发生率较高，但这些都没有任何视觉影响。
该研究得出结论，80 微米 LASIK 是 100 微米 LASIK 的有效且安全的替代方案，尤其是对高度近视患者更为有用。
