Department of Chemical Engineering, Kangwon National University, Chuncheon, Kangwon 24341, Republic of Korea.
State Key Laboratory of Intelligent Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
J Med Chem. 2024 Sep 12;67(17):14807-14819. doi: 10.1021/acs.jmedchem.4c01550. Epub 2024 Aug 26.
Deep eutectic solvents (DES) are environmentally friendly solvents with the potential to dissolve bioactive compounds without affecting their characteristics. DES has special qualities that can be customized to meet the unique characteristics of a biomolecule/active pharmaceutical ingredient (API) in accordance with various therapeutic needs, providing a reliable approach in opening the door for the creation of cutting-edge drug formulations by resolving solubility issues in pharmaceutics. This study outlines newly developing approaches to solve the problem of inefficient API extraction due to poor solubility. These emerging strategies also have the capacity to alter the chemical and physical stability of API, which triggers drug's shelf life and their possible health benefits. It is anticipated that the highlighted methods and processes will be developed to capitalize on the DES potential to improve drug solubility and delivery in the pharmaceutical sector.
深共晶溶剂 (DES) 是一种环保型溶剂，具有在不影响其特性的情况下溶解生物活性化合物的潜力。DES 具有特殊的性质，可以根据各种治疗需求定制，以满足生物分子/活性药物成分 (API) 的独特特性，为通过解决药剂学中的溶解度问题为创造前沿药物制剂提供了可靠的方法。本研究概述了新的方法来解决由于 API 溶解度差导致的提取效率低下的问题。这些新兴策略还有能力改变 API 的化学和物理稳定性，从而引发药物的保质期及其可能的健康益处。预计将开发突出的方法和工艺，以利用 DES 提高药物溶解度和药物传递的潜力。
