College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China; Research Institute of Pharmaceutical Particle Technology, Zhejiang University of Technology, Hangzhou 310014, China.
Int J Pharm. 2022 Jun 25;622:121811. doi: 10.1016/j.ijpharm.2022.121811. Epub 2022 May 10.
Deep eutectic solvents (DESs) have received increasing attention in the past decade owing to their distinguished properties including biocompatibility, tunability, thermal and chemical stability. Particularly, DESs have joined forces in pharmaceutical industry, not only to efficiently separate actives from natural products, but also to dramatically increase solubility and permeability of drugs, both are critical for the drug absorption and efficacy. As a result, lately DESs have been extensively and practically adopted as versatile drug delivery systems for different routes such as nasal, transdermal and oral administration with enhanced bioavailability. This review summarizes the emerging progress of DESs by introducing applied fabrication approaches with advantages and limitations thereof, and by highlighting the pharmaceutical applications of DESs.
深共熔溶剂（DESs）由于其具有生物相容性、可调性、热稳定性和化学稳定性等独特性质，在过去十年中受到了越来越多的关注。特别是，DESs 在制药行业中发挥了重要作用，不仅可以有效地从天然产物中分离活性成分，还可以显著提高药物的溶解度和渗透性，这对于药物吸收和疗效都至关重要。因此，最近 DESs 被广泛应用于不同途径的药物输送系统，如鼻腔、透皮和口服给药，以提高生物利用度。本综述通过介绍其应用的制造方法及其优缺点，以及强调 DESs 在药物方面的应用，总结了 DESs 的最新进展。
