Postgraduating Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Department of Nutrition, Liga Contra o Câncer, Natal, RN, Brazil.
PLoS One. 2024 Aug 26;19(8):e0307617. doi: 10.1371/journal.pone.0307617. eCollection 2024.
The thyroid cancer has the ninth larger incidence of cancer in the world. Investigations related to the exposure to metals have become important due to the sensibility of the thyroid gland to them. Studies reveal that carcinogenic progressions are associated to the deficiency of the essential trace elements. In this context, the zinc is highlighted, essential for the metabolism of the thyroidal hormone and has a potential relation with the pathogenesis of the thyroid cancer. The objective of this systematic review and meta-analysis is to evaluate the low serum zinc as a risk factor for thyroid cancer in adults.
PubMed/MEDLINE, Scopus, Embase and LILACS databases will be searched for observational studies investigating the low serum zinc as a risk factor for thyroid cancer in adults. No language or publication period restrictions will be imposed. The primary outcome will be that the low serum zinc is a risk factor for thyroid cancer. Three independent reviewers will select the studies and extract data from the original publications. The risk-of-bias will be assessed by using the Newcastle-Ottawa Quality Assessment Scale (NOS). Data synthesis will be performed using the R software (V.4.3.1) and to assess heterogeneity, we will compute the I2 statistic and the results will be based on either random-effects or fixed-effects models, depending on the heterogeneity. The Grading of Recommendations, Development, and Evaluation (GRADE) system will be used to evaluate the reliability and quality of evidence.
International Prospective Register of Systematic Reviews (PROSPERO) CRD42023463747.
甲状腺癌是世界上第九大常见癌症。由于甲状腺对金属敏感，因此与金属暴露相关的研究变得尤为重要。研究表明，致癌进展与必需微量元素的缺乏有关。在这种情况下，锌尤为突出，它是甲状腺激素代谢所必需的，并且与甲状腺癌的发病机制有潜在关系。本系统评价和荟萃分析的目的是评估血清锌水平低是否是成人甲状腺癌的危险因素。
将在 PubMed/MEDLINE、Scopus、Embase 和 LILACS 数据库中搜索观察性研究，以评估血清锌水平低是否是成人甲状腺癌的危险因素。不限制语言或出版时间。主要结局是血清锌水平低是甲状腺癌的危险因素。三位独立评审员将选择研究并从原始出版物中提取数据。使用纽卡斯尔-渥太华质量评估量表（NOS）评估偏倚风险。使用 R 软件（V.4.3.1）进行数据综合，并通过计算 I2 统计量来评估异质性，结果将基于随机效应或固定效应模型，具体取决于异质性。将使用推荐分级、评估、发展（GRADE）系统来评估证据的可靠性和质量。
国际系统评价注册中心（PROSPERO）CRD42023463747。
