Soares Aline Alves, Nagashima Yasmin Guerreiro, Piuvezam Grasiela, Alves Camila Xavier, Medeiros Kleyton Santos de, Lopes Márcia Marília Gomes Dantas, Brandao-Neto Jose
Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil.
Department of Nutrition, Liga Contra o Câncer, Natal 59062-000, RN, Brazil.
Nutrients. 2025 Aug 29;17(17):2820. doi: 10.3390/nu17172820.
: Thyroid cancer (TC) represents the most common group of endocrine tumors, and its incidence has increased over the last four decades. The imbalance of trace elements, such as zinc (Zn), has been investigated due to the thyroid's sensitivity to these elements. Zn is essential for thyroid hormone action and may be involved in the pathogenesis of TC. This systematic review and meta-analysis aim to contribute to the discussion on the association between low serum Zn concentrations and the occurrence of TC. : The search was carried out in the PubMed/MEDLINE, Scopus, Embase, LILACS and Web of Science databases, including observational studies published until December 2024. The primary outcome was low serum Zn concentration and the occurrence of TC. Three independent reviewers selected the studies and extracted the data from the original publications. The risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale. Data analysis was performed using R software (V.4.3.1), and heterogeneity was calculated using the statistic, with results based on random effects models. : A total of 10 studies ( = 7 case-control and = 3 cross-sectional) with sample sizes ranging from 44 to 294 individuals were included. The results indicated that serum Zn levels were not significantly lower in patients with TC compared with healthy controls (mean difference: -251.77; 95% confidence interval: -699.09, 195.54; = 100%, very low certainty). : Further investigations, including rigorously designed observational studies with representative samples and improved control of potential confounding variables are indispensable.
甲状腺癌（TC）是最常见的内分泌肿瘤类型，在过去四十年中其发病率呈上升趋势。由于甲状腺对锌（Zn）等微量元素敏感，因此对微量元素失衡情况进行了研究。锌对于甲状腺激素的作用至关重要，可能参与了甲状腺癌的发病机制。本系统评价和荟萃分析旨在促进关于低血清锌浓度与甲状腺癌发生之间关联的讨论。：检索在PubMed/MEDLINE、Scopus、Embase、LILACS和Web of Science数据库中进行，纳入截至2024年12月发表的观察性研究。主要结局是低血清锌浓度与甲状腺癌的发生。三位独立评审员筛选研究并从原始出版物中提取数据。使用纽卡斯尔-渥太华质量评估量表评估偏倚风险。使用R软件（V.4.3.1）进行数据分析，使用统计量计算异质性，结果基于随机效应模型。：共纳入10项研究（7项病例对照研究和3项横断面研究），样本量从44至294人不等。结果表明，与健康对照相比，甲状腺癌患者的血清锌水平并无显著降低（平均差异：-251.77；95%置信区间：-699.09，195.54；I² = 100%，极低确定性）。：进一步的研究，包括设计严谨、具有代表性样本且能更好控制潜在混杂变量的观察性研究，是必不可少的。
