Department of Breast and Thyroid Gland Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, 410005, China.
Department of General Surgery, Sir Run Run Hospital of Nanjing Medical University, Nanjing, Jiangsu, 211166, China.
J Mater Chem B. 2024 Jul 3;12(26):6285-6304. doi: 10.1039/d4tb00483c.
Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), has the advantages of spatiotemporal selectivity, non-invasiveness, and negligible drug resistance. Phototherapy has been approved for treating superficial epidermal tumors. However, its therapeutic efficacy is limited by the hypoxic tumor microenvironment and the highly expressed heat shock protein. Moreover, poor tissue penetration and focused irradiation laser region in phototherapy make treating deep tissues and metastatic tumors challenging. Combination therapy strategies, which integrate the advantages of each treatment and overcome their disadvantages, can significantly improve the therapeutic efficacy. Recently, many combination therapy strategies have been reported. Our study summarizes the strategies used for combining phototherapy with other cancer treatments such as chemotherapy, immunotherapy, sonodynamic therapy, gas therapy, starvation therapy, and chemodynamic therapy. Some research cases were selected to analyze the combination therapy effect, delivery platform feature, and synergetic anticancer mechanisms. Moreover, additional research cases are summarized in the tables. This review provides strong evidence that phototherapy-based combination strategies can enhance the anticancer effect compared with phototherapy alone. Additionally, the challenges and future perspectives associated with these combinational therapies are discussed.
光疗，包括光热疗法（PTT）和光动力疗法（PDT），具有时空选择性、非侵入性和可忽略的耐药性等优点。光疗已被批准用于治疗表浅性表皮肿瘤。然而，其治疗效果受到缺氧肿瘤微环境和高度表达的热休克蛋白的限制。此外，光疗中较差的组织穿透性和聚焦的辐照激光区域使得治疗深部组织和转移性肿瘤具有挑战性。联合治疗策略，整合了每种治疗方法的优势并克服了其缺点，可以显著提高治疗效果。最近，已经报道了许多联合治疗策略。我们的研究总结了将光疗与其他癌症治疗方法（如化疗、免疫疗法、声动力学疗法、气体疗法、饥饿疗法和化学动力学疗法）相结合的策略。选择了一些研究案例来分析联合治疗效果、递送平台特征和协同抗癌机制。此外，还在表格中总结了其他研究案例。本综述提供了有力的证据表明，基于光疗的联合策略可以比单独光疗增强抗癌效果。此外，还讨论了这些组合疗法所面临的挑战和未来展望。
