Mutagenicity and Genotoxicity Assessment of DMLL10 Isolated from Kimchi.

DMLL10 is a microorganism specific to kimchi fermentation. In this study, we sought to evaluate the toxicity of this strain, which was newly isolated from kimchi, to determine its safety as a food ingredient. Bacterial reverse mutation assay, chromosomal aberration assay, and mammalian cell in vitro micronucleus assay were performed to assess the genetic toxicity of DMLL10. The strain did not induce mutagenicity in TA98, TA100, TA1535, TA1537, or WP2uvrA, with or without metabolic activation of S9 mixture. The oral administration of DMLL10 also did not significantly increase the number of micronucleated polychromatic erythrocytes, or the mean ratio of polychromatic to total erythrocytes. Additionally, DMLL10 did not cause a significant chromosomal aberration in CHU/IL cells in the presence or absence of S9 activation. Therefore, DMLL10 can be suggested as a functional food ingredient with reliability and safety.