Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan 31151, Republic of Korea.
Probiotics Microbiome Convergence Center, Asan 31538, Republic of Korea.
J Microbiol Biotechnol. 2020 Jul 28;30(7):1051-1059. doi: 10.4014/jmb.2003.03007.
Overproduction and accumulation of melanin in the skin will darken the skin and cause skin disorders. So far, components that can inhibit tyrosinase, a melanin synthase of melanocytes, have been developed and used as ingredients of cosmetics or pharmaceutical products. However, most of existing substances can only inhibit the biosynthesis of melanin while melanin that is already synthesized and deposited is not directly decomposed. Thus, their effects in decreasing melanin concentration in the skin are weak. To overcome the limitation of existing therapeutic agents, we started to develop a substance that could directly biodegrade melanin. We screened traditional fermented food microorganisms for their abilities to direct biodegrade melanin. As a result, we found that a kimchi-derived PMC48 had a direct melanin-degrading effect. This PMC48 strain is a new strain, different from strains reported so far. It not only directly degrades melanin, but also has tyrosinase-inhibiting effect. It has a direct melanindecomposition effect. It exceeds existing melanin synthesis-inhibiting technology. It is expected to be of high value as a raw material for melanin degradation drugs and cosmetics.
黑色素在皮肤中的过度产生和积累会使皮肤变暗，并导致皮肤失调。到目前为止，已经开发出了能够抑制黑色素合成酶——黑素细胞中的酪氨酸酶的成分，并将其用作化妆品或医药产品的成分。然而，大多数现有物质只能抑制黑色素的生物合成，而已经合成并沉积的黑色素则不能直接分解。因此，它们在降低皮肤中黑色素浓度方面的效果较弱。为了克服现有治疗剂的局限性，我们开始开发一种可以直接生物降解黑色素的物质。我们筛选了传统发酵食品微生物，以评估它们直接生物降解黑色素的能力。结果发现，一种源于泡菜的 PMC48 具有直接的黑色素降解作用。这种 PMC48 菌株是一种新菌株，与迄今为止报道的菌株不同。它不仅可以直接降解黑色素，还具有抑制酪氨酸酶的作用。它具有直接的黑色素分解作用。它超过了现有的黑色素合成抑制技术。预计它将作为黑色素降解药物和化妆品的原料具有很高的价值。
