Mood Disorders Program and Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, 100 West 5th Street, Hamilton, ON, L8N 3K7, Canada.
Department of Psychiatry and Behavioural Neurosciences, McMaster University, 100 West 5th Street, Hamilton, ON, L8N 3K7, Canada.
Curr Psychiatry Rep. 2024 Oct;26(10):530-542. doi: 10.1007/s11920-024-01527-y. Epub 2024 Aug 27.
To explore the relationship between early life trauma, hormonal sensitivity, and psychiatric disorders across female-reproductive life events, with a focus on the neurobiological mechanisms.
Childhood trauma significantly increases the risk of subsequent mood disorders during periods of intense hormonal fluctuation such as premenstrual, pregnancy, postpartum, and perimenopause. Neurobiological changes resulting from early trauma influence emotion regulation, which emerges as a key predisposing, exacerbating, and perpetuating factor to hormonal sensitivity and subsequent psychiatric symptoms. We identified altered stress response and allopregnanolone imbalance, bias in cognitive processing of emotions, neuroimage correlates and sleep disturbances as potential underlying neurobiological mechanisms. This review integrates cumulative findings supporting a theoretical framework linking early life trauma to hormonal sensitivity and mood disorders. We propose that some women might be more susceptible to such hormonal fluctuations because of emotion dysregulation following significant early life trauma.
探讨女性生殖生活事件中早期生活创伤、激素敏感性与精神障碍之间的关系，重点探讨神经生物学机制。
儿童期创伤显著增加了经前期、妊娠、产后和围绝经期等激素剧烈波动期间后续情绪障碍的风险。早期创伤引起的神经生物学变化影响情绪调节，这成为激素敏感性和随后精神症状的一个关键易患、加重和持续因素。我们发现应激反应和异孕烯醇酮失衡、情绪认知加工偏差、神经影像学相关性和睡眠障碍等潜在的神经生物学机制发生改变。本综述综合了支持将早期生活创伤与激素敏感性和情绪障碍联系起来的理论框架的累积研究结果。我们提出，由于重大早期生活创伤后情绪失调，一些女性可能更容易受到这种激素波动的影响。
