Wang Jing, Luo Changyong, Wang Zhendong, Liu Tiegang, Bai Chen, Wang Yang, Tian Yuanshuo, Li Qianqian, Wang Zhaoxin, Wu Liqun, Wang Sumei, Gu Xiaohong
Pediatric Department, Wangjing Hospital of CACMS, Beijing, China.
Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Front Pediatr. 2024 Aug 12;12:1360470. doi: 10.3389/fped.2024.1360470. eCollection 2024.
This retrospective study aims to investigate the treatment of tic disorder (TD) in Dongfang Hospital affiliated with Beijing University of Chinese Medicine, explore its underlying mechanism, and provide valuable insights for future research and clinical management of TD.
The electronic medical records of children with TD, from 2015 to 2021, were extracted from the information system of Dongfang Hospital affiliated with Beijing University of Chinese Medicine. The clinical characteristics of TD, utilization patterns of Chinese herbal medicine and synthetic drugs in prescriptions, as well as their pharmacological effects, were statistically described and categorized. In addition, association rules and network pharmacology were employed to identify core prescriptions (CPs) and elucidate their microscopic molecular mechanisms in treating TD.
The age range of the children was from 6 to 11 years, with a higher proportion of male participants than female ones. The average duration of treatment was 6 weeks. Regimen Z for the treatment of TD can be summarized as follows: Chinese herbal medicine [Saposhnikoviae Radix (FangFeng), Puerariae Lobatae Radix (GeGen), Uncariae Ramulus cum Uncis (GouTeng), Acori Tatarinowii Rhizoma (ShiChangPu), Chuanxiong Rhizoma (ChuanXiong)] and vitamins [lysine, inosite, and vitamin B12 oral solution] form the basic treatment, combined with immunomodulators, antibiotics, electrolyte-balancing agents, and antiallergic agents. CPs primarily exerted their effects through the modulation of gene expression (transcription), the immune system, and signal transduction pathways, with interleukin-4 and interleukin-13 pathways being particularly crucial. Among the lysine synthetic drugs used, inosite and vitamin B12 oral solution were the most frequently prescribed.
The regimen Z drug treatment holds significant importance in the field, as it exerts its therapeutic effects through a multitude of pathways and intricate interventions. Chinese herbal medicine primarily regulates immune system-related pathways, while synthetic drugs predominantly consist of vitamins.
本回顾性研究旨在探讨北京中医药大学东方医院抽动障碍（TD）的治疗方法，探索其潜在机制，并为TD的未来研究和临床管理提供有价值的见解。
从北京中医药大学东方医院信息系统中提取2015年至2021年TD患儿的电子病历。对TD的临床特征、中药和合成药物在处方中的使用模式及其药理作用进行统计描述和分类。此外，采用关联规则和网络药理学方法识别核心处方（CPs），并阐明其治疗TD的微观分子机制。
患儿年龄范围为6至11岁，男性参与者比例高于女性。平均治疗时间为6周。治疗TD的Z方案可总结如下：中药[防风、葛根、钩藤、石菖蒲、川芎]和维生素[赖氨酸、肌醇和维生素B12口服液]构成基本治疗，联合免疫调节剂、抗生素、电解质平衡剂和抗过敏剂。CPs主要通过调节基因表达（转录）、免疫系统和信号转导途径发挥作用，其中白细胞介素-4和白细胞介素-13途径尤为关键。在使用的赖氨酸合成药物中，肌醇和维生素B12口服液是最常开具的。
Z方案药物治疗在该领域具有重要意义，因为它通过多种途径和复杂干预发挥治疗作用。中药主要调节免疫系统相关途径，而合成药物主要由维生素组成。
