Li Minxiong, Xia Wenzheng, Khoong Yi Min, Huang Lujia, Huang Xin, Liang Hsin, Zhao Yun, Mao Jiayi, Yu Haijun, Zan Tao
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Biomater Res. 2023 Sep 16;27(1):87. doi: 10.1186/s40824-023-00426-2.
The global increase of cutaneous wounds imposes huge health and financial burdens on patients and society. Despite improved wound healing outcomes, conventional wound dressings are far from ideal, owing to the complex healing process. Smart wound dressings, which are sensitive to or interact with changes in wound condition or environment, have been proposed as appealing therapeutic platforms to effectively facilitate wound healing. In this review, the wound healing processes and features of existing biomaterials are firstly introduced, followed by summarizing the mechanisms of smart responsive materials. Afterwards, recent advances and designs in smart and versatile materials of extensive applications for cutaneous wound healing were submarined. Finally, clinical progresses, challenges and future perspectives of the smart wound dressing are discussed. Overall, by mapping the composition and intrinsic structure of smart responsive materials to their individual needs of cutaneous wounds, with particular attention to the responsive mechanisms, this review is promising to advance further progress in designing smart responsive materials for wounds and drive clinical translation.
皮肤伤口在全球范围内的增加给患者和社会带来了巨大的健康和经济负担。尽管伤口愈合效果有所改善，但由于愈合过程复杂，传统伤口敷料远非理想之选。对伤口状况或环境变化敏感或能与之相互作用的智能伤口敷料，已被提议作为有效促进伤口愈合的有吸引力的治疗平台。在本综述中，首先介绍伤口愈合过程和现有生物材料的特点，接着总结智能响应材料的作用机制。随后，着重探讨了广泛应用于皮肤伤口愈合的智能多功能材料的最新进展和设计。最后，讨论了智能伤口敷料的临床进展、挑战及未来展望。总体而言，通过将智能响应材料的组成和内在结构与皮肤伤口的个体需求相对应，尤其关注响应机制，本综述有望推动智能响应伤口材料设计取得进一步进展并推动临床转化。
