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在葡萄膜炎和广泛睫状体扁平部纤维化患者中进行无需切开巩膜造口术的Retisert植入术。

Retisert implantation without incisional sclerotomy in patients with uveitis and extensive pars plana fibrosis.

作者信息

Taha Abu Tahir, Wu Joshua, Schallhorn Julie M, Stewart Jay M

机构信息

University of California, Department of Ophthalmology, San Francisco, CA, USA.

Zuckerberg San Francisco General Hospital and Trauma Center, Department of Ophthalmology, San Francisco, CA, USA.

出版信息

Am J Ophthalmol Case Rep. 2024 Jul 31;36:102135. doi: 10.1016/j.ajoc.2024.102135. eCollection 2024 Dec.

DOI:10.1016/j.ajoc.2024.102135
PMID:39188855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11347055/
Abstract

PURPOSE

To describe an alternate surgical technique for fluocinolone acetonide (Retisert) implantation in patients with extensive pars plana and pars plicata fibrosis secondary to chronic non-infectious uveitis.

METHODS

This retrospective, interventional case series included five eyes of four patients who had poorly controlled chronic non-infectious uveitis. Retisert was implanted successfully using a novel approach. The device was introduced into the posterior segment through the anterior chamber and posterior capsulotomy, forgoing the need for full-thickness scleral incision and minimizing the risk of retinal detachment and associated complications.

RESULTS

Five eyes underwent passage of Retisert implant through the anterior segment via a limbal incision and a posterior capsulotomy. Retisert was successfully implanted in all patients in the posterior chamber. No intraoperative or postoperative complications were encountered. Up until the last follow-up, all eyes demonstrated the stability of the implant. Visual acuity improved in four out of five eyes.

CONCLUSIONS

Retisert can be implanted via the anterior chamber in patients with extensive fibrosis in the pars plana and pars plicata regions. This approach may minimize the risk of retinal traction and damage to the implant when compared to the traditional full-thickness sclerotomy method in these high-risk cases.

摘要

目的

描述一种用于患有慢性非感染性葡萄膜炎继发广泛睫状体扁平部和睫状突纤维化患者的氟轻松丙酮化物(Retisert)植入的替代手术技术。

方法

本回顾性、介入性病例系列包括4例慢性非感染性葡萄膜炎控制不佳患者的5只眼。采用一种新方法成功植入Retisert。该装置通过前房和后囊切开术引入眼后段,无需进行全层巩膜切口,将视网膜脱离及相关并发症的风险降至最低。

结果

5只眼通过角膜缘切口和后囊切开术经前段植入Retisert。Retisert在所有患者的后房均成功植入。未发生术中或术后并发症。直至最后一次随访,所有眼内植入物均保持稳定。5只眼中4只眼的视力得到改善。

结论

对于睫状体扁平部和睫状突区域存在广泛纤维化的患者,可通过前房植入Retisert。与这些高风险病例的传统全层巩膜切开术方法相比,该方法可将视网膜牵拉和植入物损伤的风险降至最低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3d9/11347055/de225b406833/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3d9/11347055/de225b406833/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3d9/11347055/de225b406833/gr1.jpg

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本文引用的文献

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Hypotony in uveitis: an overview of medical and surgical management.葡萄膜炎相关性低眼压:医学和手术治疗概述。
Br J Ophthalmol. 2023 Nov 22;107(12):1765-1770. doi: 10.1136/bjo-2022-322814.
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Pathogenesis and current therapies for non-infectious uveitis.非感染性葡萄膜炎的发病机制和当前治疗方法。
Clin Exp Med. 2023 Aug;23(4):1089-1106. doi: 10.1007/s10238-022-00954-6. Epub 2022 Nov 24.
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Epidemiology and Risk Factors in Non-infectious Uveitis: A Systematic Review.非感染性葡萄膜炎的流行病学与危险因素:一项系统综述
Front Med (Lausanne). 2021 Sep 10;8:695904. doi: 10.3389/fmed.2021.695904. eCollection 2021.
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Diagnostic imaging of the ciliary body: Technologies, outcomes, and future perspectives.睫状体的诊断影像学:技术、结果和未来展望。
Eur J Ophthalmol. 2022 Jan;32(1):75-88. doi: 10.1177/11206721211031409. Epub 2021 Jul 7.
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Outcomes and Complications Associated with Noninfectious Uveitis in Patients Presenting with Rhegmatogenous Retinal Detachment.与孔源性视网膜脱离患者相关的非感染性葡萄膜炎的结局和并发症。
Ophthalmol Retina. 2020 Aug;4(8):823-828. doi: 10.1016/j.oret.2020.02.010. Epub 2020 Feb 28.
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Characterization of cyclitic membranes by ultrabiomicroscopy in patients with pars planitis.中间葡萄膜炎患者中环状视网膜病变膜的超微显微镜特征分析
J Ophthalmic Inflamm Infect. 2020 Jan 27;10(1):7. doi: 10.1186/s12348-020-0194-7.
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Clinical characteristics, treatment and ocular complications of HLA-B27-related anterior uveitis and HLA-B27-non related anterior uveitis.HLA - B27相关性前葡萄膜炎和HLA - B27非相关性前葡萄膜炎的临床特征、治疗及眼部并发症
Reumatol Clin. 2016 Sep-Oct;12(5):244-7. doi: 10.1016/j.reuma.2015.11.008. Epub 2015 Dec 18.
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Immunopathogenic Background of Pars Planitis.睫状体平坦部炎的免疫致病背景
Arch Immunol Ther Exp (Warsz). 2016 Apr;64(2):127-37. doi: 10.1007/s00005-015-0361-y. Epub 2015 Oct 5.
9
Scleral melt following Retisert intravitreal fluocinolone implant.雷珠单抗玻璃体内注射氟轻松植入术后巩膜溶解
Drug Des Devel Ther. 2014 Nov 28;8:2373-5. doi: 10.2147/DDDT.S66634. eCollection 2014.
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Spontaneous dissociation and dislocation of Retisert pellet.Retisert 微球自发分离和脱位。
Ocul Immunol Inflamm. 2013;21(1):87-9. doi: 10.3109/09273948.2012.736585.