Institute of Chemistry, University of the Philippines Diliman, Philippines.
Dalton Trans. 2024 Sep 18;53(36):14971-14974. doi: 10.1039/d4dt01773k.
A marine-derived peptide labelled with a Gd(III)-chelate was found to self-assemble depending on the solution pH, accompanied by changes in -relaxivity () values when in the dispersed or self-assembled form. Such pH-responsive behavior can be advantageous in the development of macromolecular magnetic resonance imaging (MRI) contrast agents which monitor the tissue physiology.
研究发现，一种标记有 Gd(III)-螯合物的海洋来源肽会根据溶液 pH 值自组装，同时在分散或自组装形式时 -弛豫率 () 值发生变化。这种 pH 响应行为在开发监测组织生理学的大分子磁共振成像（MRI）造影剂方面具有优势。
