CSIR-Central Mechanical Engineering Research Institute, M.G. Avenue, Durgapur, 713209, India.
Academy of Scientific and Innovative Research (AcSIR), AcSIR Headquarters CSIR-HRDC Campus, Postal Staff College Area, Sector 19, Kamala Nehru Nagar, Ghaziabad 201002, Uttar Pradesh, India.
Anal Methods. 2024 Sep 19;16(36):6183-6192. doi: 10.1039/d4ay01063a.
2D MXenes have been used as electrochemical sensor materials, but their output current signal remains weak in point of care (PoC) settings. To address this issue, here we report a novel MXene-supported cobalt-MOF-based nanocomposite, which is used with a carbon black (CB) ink and 3-D printed as the CoMOF-MXene@CB layered electrode structure for the development of a sensor electrode and a PoC chip for electrochemical detection of blood creatinine with an enhanced current range, specificity, and sensitivity. The limit of detection (LOD) and sensitivity of the fabricated sensor were found to be 0.005 μM and 1.1 μA μM cm, which are 44 times lower and 32 times enhanced, respectively, as compared to the existing literature report (LOD 0.22 μM and sensitivity 0.034 μA μM) for creatinine sensing in PoC settings. The sensor exhibited an excellent linear sensor response ranging from 10 to 800 μM and good reproducibility, stability, and selectivity with significant accuracy. These characteristics helped the sensor to accurately determine the creatinine levels in real human serum samples.
2D MXenes 已被用作电化学传感器材料，但在即时检测 (Point-of-care，PoC) 环境下，其输出电流信号仍然较弱。针对这一问题，我们在此报告了一种新型的 MXene 负载的钴-金属有机骨架 (MOF) 基纳米复合材料，该材料与炭黑 (Carbon Black，CB) 墨水一起使用，并通过 3D 打印制成 CoMOF-MXene@CB 分层电极结构，用于开发用于电化学检测血液肌酐的传感器电极和 PoC 芯片，以提高电流范围、特异性和灵敏度。所制备的传感器的检测限 (Limit of Detection，LOD) 和灵敏度分别为 0.005 μM 和 1.1 μA μM cm，与现有文献报道 (PoC 环境下肌酐检测的 LOD 为 0.22 μM 和灵敏度为 0.034 μA μM) 相比，分别降低了 44 倍和提高了 32 倍。该传感器在 10 至 800 μM 的范围内表现出优异的线性传感器响应，具有良好的重现性、稳定性和选择性，并且具有显著的准确性。这些特性有助于传感器准确地测定真实人体血清样本中的肌酐水平。
