Laboratory of Animal Pathology, Program in Bioexperimentation, School of Agricultural Sciences, Innovation and Business, UPF, Passo Fundo, Rio Grande do Sul, Brazil.
Laboratory of Veterinary Pathology, Veterinary Faculty, Federal University of Mato Grosso, Av. Fernando Corrêa da Costa 2367, Cuiabá, Mato Grosso, CEP: 78060900, Brazil.
Vet Res Commun. 2024 Dec;48(6):4067-4071. doi: 10.1007/s11259-024-10476-z. Epub 2024 Aug 27.
Lymphoma is the most common tumor of hematopoietic origin in horses. The course of the disease and clinical signs vary greatly, depending on tumor location and extent. The aim of this report is to describe the occurrence of T-cell-rich oral large B-cell lymphoma with marked local infiltration in a 25-year-old Crioula mare. The mare showed an increase in volume on the right side of its face, dyspnea, anorexia, and progressive weight loss. The clinical assessment showed that the lesion was located in the rostral and caudal sinuses and was markedly invasive to adjacent structures. The autopsy revealed a yellow mass with a soft to firm consistency, infiltrating multiple bones in the skull, and extensively invading the hard palate and masseter muscle. Histologically the mass comprised an undifferentiated malignant neoplasm characterized by a densely cellular neoplasm composed of large CD20 + neoplastic B-lymphocytes admixed with sheets of small, CD3 + reactive T-lymphocytes supported by delicate fibrovascular stroma leading to the diagnosis of oral T-cell-rich large B-cell lymphoma.
淋巴瘤是马属动物中最常见的造血组织来源的肿瘤。疾病的病程和临床症状差异很大，取决于肿瘤的位置和范围。本报告的目的是描述一例 25 岁克里奥罗母马发生的伴有明显局部浸润的 T 细胞-rich 口腔大 B 细胞淋巴瘤。该母马表现出面部右侧体积增大、呼吸困难、食欲不振和进行性体重减轻。临床评估显示病变位于额窦和蝶窦，且对邻近结构具有明显的侵袭性。尸检显示黄色肿块，质地柔软到坚硬，浸润颅骨内的多块骨头，并广泛侵犯硬腭和咬肌。组织学上，肿块由未分化的恶性肿瘤组成，特征为密集的细胞性肿瘤，由大量 CD20+ 肿瘤性 B 淋巴细胞与片状的小 CD3+ 反应性 T 淋巴细胞混合组成，由纤细的纤维血管基质支持，诊断为口腔 T 细胞-rich 大 B 细胞淋巴瘤。
