Takahashi K, Saijo N, Kimata M, Sasaki Y, Fujita J, Futami H, Shimizu E, Eguchi K, Shinkai T, Tominaga K
J Cancer Res Clin Oncol. 1985;109(1):78-81. doi: 10.1007/BF01884259.
The achievable concentrations of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl-3-nitrosourea (ACNU), adriamycin, mitomycin C, vindesine, and epipodophyllotoxin suppressed the natural killer (NK) activity of human peripheral blood lymphocytes in vitro, whereas NK activity was not decreased 24 h after incubation with the maximum achievable concentration of cisplatin (cDDP). NK activity of patients treated with 80 mg per square meter of cDDP alone was not decreased for 3 weeks after cDDP administration. In contrast, NK activity of patients treated with the same dose of cDDP and methylprednisolone was significantly decreased 1 week after cDDP administration. It was concluded that methylprednisolone, used as an antiemetic agent, had an immunosuppressive effect.
1-(4-氨基-2-甲基-5-嘧啶基)甲基-3-(2-氯乙基)-3-亚硝基脲（ACNU）、阿霉素、丝裂霉素C、长春地辛和表鬼臼毒素所能达到的浓度在体外抑制人外周血淋巴细胞的自然杀伤（NK）活性，而与顺铂（cDDP）的最大可达到浓度孵育24小时后，NK活性并未降低。单独使用每平方米80毫克cDDP治疗的患者，其NK活性在cDDP给药后3周内未降低。相比之下，用相同剂量的cDDP和甲基强的松龙治疗的患者，在cDDP给药1周后NK活性显著降低。得出的结论是，用作止吐剂的甲基强的松龙具有免疫抑制作用。
