Jones Owen, Li Zhihao, Magyar Christian Tibor Josef, Goldaracena Nicolas, Sayed Blayne A, Ghanekar Anand, Cattral Mark, Selzner Nazia, Sapisochin Gonzalo
Ajmera Transplant Centre, HBP & Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada.
Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Liver Transpl. 2025 Mar 1;31(3):287-297. doi: 10.1097/LVT.0000000000000473. Epub 2024 Aug 28.
This study aims to identify and categorize nonmedical barriers encountered by recipients, donors, and health care providers in the context of living donor liver transplantation (LDLT). Liver transplantation is vital for individuals with liver failure, yet high mortality rates on the transplant waitlist persist. LDLT was introduced to address deceased donor organ shortages; however, its adoption varies widely across regions, prompting the need to explore barriers hindering its implementation. The scoping review employed inclusion and exclusion criteria to identify studies focusing on nonmedical barriers to LDLT in both adult and pediatric populations. Qualitative, quantitative, and mixed-method studies were considered, covering the period from January 2005 to February 2023. The review's search strategy was conducted in the Ovid MEDLINE and Ovid EMBASE databases. Studies meeting the criteria were assessed for their characteristics and findings, which were synthesized into recipient, donor, and provider-level barriers. Among 2394 initially screened articles, 17 studies were eligible for inclusion. Recipient-level barriers encompassed systemic disparities in access, limited social support, immigration status, and inadequate awareness of LDLT. Donor-level barriers involved surgery-related risks, recovery time concerns, financial burdens, and religious beliefs. Provider-level barriers highlighted institutional support inadequacies and specialized surgeon shortages. The scoping review underscores nonmedical barriers to LDLT across recipient, donor, and provider levels. These barriers include socioeconomic disparities, information gaps, and inadequate institutional support. The findings underscore the need for comprehensive national efforts to raise awareness about LDLT and provide essential financial support.
本研究旨在识别和分类活体肝移植(LDLT)背景下受者、供者和医疗服务提供者所遇到的非医学障碍。肝移植对于肝功能衰竭患者至关重要,但移植等待名单上的高死亡率仍然存在。引入LDLT是为了解决已故供者器官短缺的问题;然而,其应用在各地区差异很大,这促使人们需要探索阻碍其实施的障碍。范围综述采用纳入和排除标准,以识别关注成人和儿童人群中LDLT非医学障碍的研究。定性、定量和混合方法研究均在考虑范围内,涵盖2005年1月至2023年2月期间。综述的检索策略在Ovid MEDLINE和Ovid EMBASE数据库中进行。对符合标准的研究进行特征和结果评估,并将其综合为受者、供者和提供者层面的障碍。在最初筛选的2394篇文章中,有17项研究符合纳入标准。受者层面的障碍包括获得医疗服务的系统性差异、社会支持有限、移民身份以及对LDLT的认识不足。供者层面的障碍涉及手术相关风险、对恢复时间的担忧、经济负担和宗教信仰。提供者层面的障碍突出了机构支持不足和专业外科医生短缺的问题。范围综述强调了LDLT在受者、供者和提供者层面存在的非医学障碍。这些障碍包括社会经济差异、信息差距和机构支持不足。研究结果强调需要国家做出全面努力,以提高对LDLT的认识并提供必要的财政支持。