Masuda A, Shibasaki T, Nakahara M, Imaki T, Kiyosawa Y, Jibiki K, Demura H, Shizume K, Ling N
J Clin Endocrinol Metab. 1985 Mar;60(3):523-6. doi: 10.1210/jcem-60-3-523.
The effect of glucose on GH-releasing hormone (GHRH)-mediated GH secretion was examined in six normal young men. In two paired experiments, the six men drank a 75-g glucose solution or an equal volume of water 30 min before receiving, iv, 100 micrograms of the 44-amino acid form of human pancreatic GHRH (hGHRH-44). One week later, the same men underwent an identical experimental protocol in a cross-over trial. Basal plasma GH concentrations before hGHRH-44 administration were not statistically different in the two experiments [glucose experiment, 2.1 +/- 0.1 (+/- SE) ng/ml; water experiment, 2.6 +/- 0.6 ng/ml]. The mean peak plasma GH level occurred 30 min after hGHRH-44 administration in both experiments. However, the mean GH response was significantly diminished when the men received glucose (8.12 +/- 1.12 ng/ml) compared to that when they received only water (23.70 +/- 8.46 ng/ml; P less than 0.01). Thus, hyperglycemia may exert an inhibitory effect on the plasma GH response to hGHRH-44.
在6名正常年轻男性中研究了葡萄糖对生长激素释放激素（GHRH）介导的生长激素（GH）分泌的影响。在两项配对实验中，这6名男性在静脉注射100微克44氨基酸形式的人胰腺GHRH（hGHRH - 44）前30分钟，饮用了75克葡萄糖溶液或等体积的水。一周后，同样这些男性在交叉试验中接受相同的实验方案。在这两项实验中，给予hGHRH - 44之前的基础血浆GH浓度无统计学差异[葡萄糖实验，2.1±0.1（±SE）纳克/毫升；水实验，2.6±0.6纳克/毫升]。在两项实验中，血浆GH平均峰值水平均在给予hGHRH - 44后30分钟出现。然而，与仅饮水时（23.70±8.46纳克/毫升；P<0.01）相比，这些男性饮用葡萄糖时的平均GH反应显著降低（8.12±1.12纳克/毫升）。因此，高血糖可能对血浆GH对hGHRH - 44的反应产生抑制作用。
