Singh Rohit Kumar, Verma Khyati, Kumar G C Mohan, Jalageri Mallikarjun B
Department of Mechanical Engineering, National Institute of Technology Karnataka, Surathkal, India.
J Biomater Sci Polym Ed. 2025 Feb;36(2):191-211. doi: 10.1080/09205063.2024.2396224. Epub 2024 Aug 27.
Graphene, a two-dimensional carbon nanomaterial, has garnered widespread attention across various fields due to its outstanding properties. In dental implantology, researchers are exploring the use of graphene-functionalized polymer surfaces to enhance both the osseointegration process and the long-term success of dental implants. This review consolidates evidence from in-vivo and in-vitro studies, highlighting graphene's capacity to improve bone-to-implant contact, exhibit antibacterial properties, and enhance mechanical strength. This research investigates the effects of incorporating graphene derivatives into polymer materials on tissue response and compatibility. Among 123 search results, 14 articles meeting the predefined criteria were analyzed. The study primarily focuses on assessing the impact of GO and rGO on cellular function and stability in implants. Results indicate promising improvements in cellular function and stability with the use of GO-coated or composited implants. However, it is noted that interactions between Graphene derivatives and polymers may alter the inherent properties of the materials. Therefore, further rigorous research is deemed imperative to fully elucidate their potential in human applications. Such comprehensive understanding is essential for unlocking the extensive benefits associated with the utilization of Graphene derivatives in biomedical contexts.
石墨烯是一种二维碳纳米材料，因其卓越的性能而在各个领域受到广泛关注。在牙种植学中，研究人员正在探索使用石墨烯功能化的聚合物表面，以增强骨结合过程以及牙种植体的长期成功率。这篇综述整合了体内和体外研究的证据，突出了石墨烯在改善骨与种植体接触、展现抗菌性能以及增强机械强度方面的能力。本研究调查了将石墨烯衍生物掺入聚合物材料对组织反应和相容性的影响。在123个搜索结果中，分析了14篇符合预定义标准的文章。该研究主要侧重于评估氧化石墨烯（GO）和还原氧化石墨烯（rGO）对种植体中细胞功能和稳定性的影响。结果表明，使用涂覆有GO或复合有GO的种植体在细胞功能和稳定性方面有前景良好的改善。然而，需要注意的是，石墨烯衍生物与聚合物之间的相互作用可能会改变材料的固有特性。因此，认为有必要进行进一步严格的研究，以充分阐明它们在人体应用中的潜力。这种全面的理解对于释放与在生物医学环境中利用石墨烯衍生物相关的广泛益处至关重要。
