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1
Major histocompatibility complex-restricted antigen receptor on T cells. VIII. Role of the LFA-1 molecule.T细胞上的主要组织相容性复合体限制抗原受体。VIII.淋巴细胞功能相关抗原-1分子的作用。
J Exp Med. 1985 Mar 1;161(3):635-40. doi: 10.1084/jem.161.3.635.
2
Qualitative and quantitative studies of antigen-presenting cell function by using I-A-expressing L cells.利用表达I-A的L细胞对抗抗原呈递细胞功能进行的定性和定量研究。
J Immunol. 1985 Nov;135(5):2914-22.
3
L3T4 but not LFA-1 participates in antigen presentation by Ak-positive L-cell transformants.
Immunogenetics. 1985;22(3):247-56. doi: 10.1007/BF00404484.
4
The major histocompatibility complex-restricted antigen receptor on T cells. IX. Role of accessory molecules in recognition of antigen plus isolated IA.T细胞上的主要组织相容性复合体限制抗原受体。IX. 辅助分子在抗原加分离的IA识别中的作用
J Immunol. 1986 Mar 15;136(6):2026-32.
5
Role of the LFA-1 molecule in cellular interactions required for antibody production in humans.LFA-1分子在人类抗体产生所需的细胞相互作用中的作用。
J Immunol. 1986 May 1;136(9):3198-203.
6
A rat anti-mouse T4 monoclonal antibody (H129.19) inhibits the proliferation of Ia-reactive T cell clones and delineates two phenotypically distinct (T4+, Lyt-2,3-, and T4-, Lyt-2,3+) subsets among anti-Ia cytolytic T cell clones.一种大鼠抗小鼠T4单克隆抗体（H129.19）可抑制Ia反应性T细胞克隆的增殖，并在抗Ia细胞毒性T细胞克隆中区分出两个表型不同的亚群（T4+、Lyt-2,3-和T4-、Lyt-2,3+）。
J Immunol. 1984 Jun;132(6):2775-82.
7
Role of the L3T4-antigen in T cell activation. II. Inhibition of T cell activation by monoclonal anti-L3T4 antibodies in the absence of accessory cells.L3T4抗原在T细胞激活中的作用。II. 在无辅助细胞情况下单克隆抗L3T4抗体对T细胞激活的抑制作用。
J Immunol. 1985 Oct;135(4):2237-42.
8
Effects of monoclonal antibodies directed against murine T lymphocyte cell surface antigens on lymphokine production by cloned T lymphocytes reactive with class I MHC or Mls alloantigens.针对小鼠T淋巴细胞细胞表面抗原的单克隆抗体对与I类主要组织相容性复合体（MHC）或Mls同种异体抗原反应的克隆T淋巴细胞产生淋巴因子的影响。
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Mechanisms of tumor cell capture by activated macrophages: evidence for involvement of lymphocyte function-associated (LFA)-1 antigen.活化巨噬细胞捕获肿瘤细胞的机制：淋巴细胞功能相关（LFA）-1抗原参与的证据。
J Immunol. 1986 Jun 1;136(11):4328-33.
10
Membrane Ia expression and antigen-presenting accessory cell function of L cells transfected with class II major histocompatibility complex genes.转染了II类主要组织相容性复合体基因的L细胞的膜Ia表达及抗原呈递辅助细胞功能。
J Exp Med. 1984 Nov 1;160(5):1316-37. doi: 10.1084/jem.160.5.1316.

引用本文的文献

1
Analysis of HLA-DR glycoproteins by DNA-mediated gene transfer. Definition of DR2 beta gene products and antigen presentation to T cell clones from leprosy patients.通过DNA介导的基因转移分析HLA - DR糖蛋白。DR2β基因产物的定义以及向麻风病患者T细胞克隆的抗原呈递。
J Exp Med. 1988 Apr 1;167(4):1442-58. doi: 10.1084/jem.167.4.1442.
2
T-cell clones and T-cell receptors.T细胞克隆与T细胞受体。
Microbiol Rev. 1986 Mar;50(1):50-69. doi: 10.1128/mr.50.1.50-69.1986.
3
L3T4 but not LFA-1 participates in antigen presentation by Ak-positive L-cell transformants.
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4
TAP, a novel T cell-activating protein involved in the stimulation of MHC-restricted T lymphocytes.TAP，一种参与刺激MHC限制的T淋巴细胞的新型T细胞激活蛋白。
J Exp Med. 1986 Feb 1;163(2):315-33. doi: 10.1084/jem.163.2.315.
5
Differential presentation of hepatitis B S-preS(2) particles and peptides by macrophages and B-cell like antigen-presenting cells.巨噬细胞和B细胞样抗原呈递细胞对乙型肝炎S-preS(2)颗粒和肽的差异呈递
Immunology. 1991 May;73(1):88-94.

本文引用的文献

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Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1.与巨噬细胞分化抗原Mac-1相关的白细胞表面糖蛋白的分子复杂性
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2
Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing.淋巴细胞功能相关抗原1（LFA-1）：一种与Lyt-2、3不同的表面抗原，参与T淋巴细胞介导的杀伤作用。
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3
Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.人细胞毒性T淋巴细胞的克隆分析：T4 +和T8 +效应T细胞识别不同主要组织相容性复合体区域的产物。
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4
The mouse T cell receptor: comparison of MHC-restricted receptors on two T cell hybridomas.小鼠T细胞受体：两种T细胞杂交瘤上MHC限制性受体的比较。
Cell. 1983 Oct;34(3):727-37. doi: 10.1016/0092-8674(83)90529-9.
5
Expression of H-2Dd and H-2Ld mouse major histocompatibility antigen genes in L cells after DNA-mediated gene transfer.DNA介导的基因转移后，H-2Dd和H-2Ld小鼠主要组织相容性抗原基因在L细胞中的表达。
J Immunol. 1983 Jan;130(1):463-70.
6
Human cytolytic T lymphocyte interactions with vascular endothelium and fibroblasts: role of effector and target cell molecules.人细胞溶解性T淋巴细胞与血管内皮细胞和成纤维细胞的相互作用：效应细胞和靶细胞分子的作用
J Immunol. 1984 Oct;133(4):1878-84.
7
Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.用单克隆抗体GK1.5鉴定的小鼠T细胞表面分子L3T4的特性：L3T4与人Leu-3/T4分子的相似性
J Immunol. 1983 Nov;131(5):2445-51.
8
The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product.T细胞上主要组织相容性复合体限制的抗原受体。II. L3T4产物的作用。
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T cell-mediated cytolysis: on the strength of effector-target cell interaction.
Eur J Immunol. 1983 May;13(5):424-9. doi: 10.1002/eji.1830130514.
10
The role of L3T4 in recognition of Ia by a cytotoxic, H-2Dd-specific T cell hybridoma.L3T4在一种细胞毒性、H-2Dd特异性T细胞杂交瘤识别Ia中的作用。
J Exp Med. 1984 Apr 1;159(4):1213-24. doi: 10.1084/jem.159.4.1213.

T细胞上的主要组织相容性复合体限制抗原受体。VIII.淋巴细胞功能相关抗原-1分子的作用。

Major histocompatibility complex-restricted antigen receptor on T cells. VIII. Role of the LFA-1 molecule.

作者信息

Golde W T, Kappler J W, Greenstein J, Malissen B, Hood L, Marrack P

出版信息

J Exp Med. 1985 Mar 1;161(3):635-40. doi: 10.1084/jem.161.3.635.

DOI:10.1084/jem.161.3.635
PMID:3919144
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187581/
Abstract

We show that the LFA-1 molecule on T cells does not play a role in the stimulation of T cell hybridomas by certain targets, namely antigen presented by L cell derivatives or polyvalent anti-receptor antibody. These results suggest that LFA-1 may act by binding to ligands that are not present on all cells. We hope this result will help us and others to establish the true role of LFA-1 in T cell responses.

摘要

我们发现，T细胞上的淋巴细胞功能相关抗原-1（LFA-1）分子在某些靶标刺激T细胞杂交瘤的过程中并不发挥作用，这些靶标即L细胞衍生物呈递的抗原或多价抗受体抗体。这些结果表明，LFA-1可能通过与并非所有细胞都存在的配体结合来发挥作用。我们希望这一结果将有助于我们及其他人确定LFA-1在T细胞应答中的真正作用。