T细胞上的主要组织相容性复合体限制抗原受体。VIII.淋巴细胞功能相关抗原-1分子的作用。
Major histocompatibility complex-restricted antigen receptor on T cells. VIII. Role of the LFA-1 molecule.
作者信息
Golde W T, Kappler J W, Greenstein J, Malissen B, Hood L, Marrack P
出版信息
J Exp Med. 1985 Mar 1;161(3):635-40. doi: 10.1084/jem.161.3.635.
Abstract
We show that the LFA-1 molecule on T cells does not play a role in the stimulation of T cell hybridomas by certain targets, namely antigen presented by L cell derivatives or polyvalent anti-receptor antibody. These results suggest that LFA-1 may act by binding to ligands that are not present on all cells. We hope this result will help us and others to establish the true role of LFA-1 in T cell responses.
摘要
我们发现，T细胞上的淋巴细胞功能相关抗原-1（LFA-1）分子在某些靶标刺激T细胞杂交瘤的过程中并不发挥作用，这些靶标即L细胞衍生物呈递的抗原或多价抗受体抗体。这些结果表明，LFA-1可能通过与并非所有细胞都存在的配体结合来发挥作用。我们希望这一结果将有助于我们及其他人确定LFA-1在T细胞应答中的真正作用。
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本文引用的文献
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J Exp Med. 1981 Nov 1;154(5):1517-24. doi: 10.1084/jem.154.5.1517.
2
Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing.淋巴细胞功能相关抗原1（LFA-1）：一种与Lyt-2、3不同的表面抗原，参与T淋巴细胞介导的杀伤作用。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4535-9. doi: 10.1073/pnas.78.7.4535.
3
Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.人细胞毒性T淋巴细胞的克隆分析：T4 +和T8 +效应T细胞识别不同主要组织相容性复合体区域的产物。
Proc Natl Acad Sci U S A. 1982 Jul;79(14):4395-9. doi: 10.1073/pnas.79.14.4395.
4
The mouse T cell receptor: comparison of MHC-restricted receptors on two T cell hybridomas.小鼠T细胞受体：两种T细胞杂交瘤上MHC限制性受体的比较。
Cell. 1983 Oct;34(3):727-37. doi: 10.1016/0092-8674(83)90529-9.
5
6
7
8
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9
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