Alawad Asim, Sati Wala, Ahmed Sara M I, Elgassim Moayed, Elgassim Mohamad, Balal Abderahman
Emergency Medicine Department, Hamad General Hospital, P.O. Box: 3050, Doha, Qatar.
Oxf Med Case Reports. 2024 Aug 26;2024(8):omae096. doi: 10.1093/omcr/omae096. eCollection 2024 Aug.
Melatonin, a pineal gland hormone closely associated with the circadian rhythm, has been trending over the past years as an over-the-counter medication to aid with sleep disturbances. Although generally believed to be safe, recent studies show negative inotropic and chronotropic effects on the heart rate and blood pressure in humans. Several studies suggested that melatonin induces cardiac vagal tone and affects heart rate and mean arterial pressure. Limited literature is currently available on the effects of melatonin beyond its sleep function. We present a case of a healthy 22-year-old male who visited the emergency department reporting palpitations and dizziness following the ingestion of 20 mg of melatonin. Subsequent examinations revealed marked bradycardia. Fortunately, the patient experienced spontaneous resolution of the bradycardia without necessitating intervention after a few hours of observation, and he was observed and discharged.
褪黑素是一种与昼夜节律密切相关的松果体激素，在过去几年中，作为一种非处方药物来帮助解决睡眠障碍的情况越来越普遍。尽管通常认为它是安全的，但最近的研究表明，它对人类的心率和血压有负性肌力和变时性作用。几项研究表明，褪黑素会诱发心脏迷走神经张力，影响心率和平均动脉压。目前关于褪黑素超出其睡眠功能的影响的文献有限。我们报告一例健康的22岁男性病例，该患者因摄入20毫克褪黑素后前往急诊科就诊，自述有心悸和头晕症状。随后的检查发现明显的心动过缓。幸运的是，经过几个小时的观察，患者的心动过缓自行缓解，无需干预，随后对其进行观察并出院。
