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1
Melatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metabolic syndrome.褪黑素治疗可改善代谢综合征患者的血压、血脂谱和氧化应激参数。
J Pineal Res. 2011 Apr;50(3):261-6. doi: 10.1111/j.1600-079X.2010.00835.x. Epub 2010 Dec 8.
2
Cardiac hypertrophy and remodelling: pathophysiological consequences and protective effects of melatonin.心肌肥厚与重构：褪黑素的病理生理学后果及保护作用。
J Hypertens. 2010 Sep;28 Suppl 1:S7-12. doi: 10.1097/01.hjh.0000388488.51083.2b.
3
Urinary melatonin and risk of incident hypertension among young women.尿褪黑素与年轻女性新发高血压的风险。
J Hypertens. 2010 Mar;28(3):446-51. doi: 10.1097/HJH.0b013e3283340c16.
4
Endogenous melatonin levels and the fate of exogenous melatonin: age effects.内源性褪黑素水平及外源性褪黑素的转归：年龄效应
J Gerontol A Biol Sci Med Sci. 1998 Jul;53(4):B293-8. doi: 10.1093/gerona/53a.4.b293.
5
Blood pressure modulation and cardiovascular protection by melatonin: potential mechanisms behind.褪黑素对血压的调节作用及心血管保护：潜在机制
Physiol Res. 2007;56(6):671-684. doi: 10.33549/physiolres.931236.
6
Melatonin: therapeutic and clinical utilization.褪黑素：治疗与临床应用。
Int J Clin Pract. 2007 May;61(5):835-45. doi: 10.1111/j.1742-1241.2006.01191.x. Epub 2007 Feb 13.
7
How strong is the evidence for use of beta-blockers as first-line therapy for hypertension? Systematic review and meta-analysis.β受体阻滞剂作为高血压一线治疗药物的证据有多充分？系统评价与荟萃分析。
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9
The therapeutic potential of melatonin: a review of the science.褪黑素的治疗潜力：科学综述
MedGenMed. 2004 Apr 13;6(2):46.
10
Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension.每日夜间服用褪黑素可降低原发性高血压男性患者的血压。
Hypertension. 2004 Feb;43(2):192-7. doi: 10.1161/01.HYP.0000113293.15186.3b. Epub 2004 Jan 19.

夜间给予外源性褪黑素可能是治疗β受体阻滞剂患者睡眠障碍的一种有效方法。

Night-time exogenous melatonin administration may be a beneficial treatment for sleeping disorders in beta blocker patients.

作者信息

Fares Auda

机构信息

Department of Internal Medicine, S. Johannes Hospital, Germany.

出版信息

J Cardiovasc Dis Res. 2011 Jul;2(3):153-5. doi: 10.4103/0975-3583.85261.

DOI:10.4103/0975-3583.85261
PMID:22022142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3195193/
Abstract

Sleep disorders are the common side effects of beta blockers. Beta blockers have been shown to reduce the production of melatonin via specific inhibition of adrenergic beta1-receptors. Exogenous melatonin, taken in the evening as a supplement, could reduce the central nervous system (CNS) side effects (sleep disorder) associated with beta-adrenergic receptor blockers as well as the potential risk associated with reduction of the melatonin synthesis.

摘要

睡眠障碍是β受体阻滞剂常见的副作用。研究表明，β受体阻滞剂可通过特异性抑制肾上腺素能β1受体来减少褪黑素的分泌。作为补充剂在晚上服用外源性褪黑素，可以减轻与β肾上腺素能受体阻滞剂相关的中枢神经系统（CNS）副作用（睡眠障碍）以及与褪黑素合成减少相关的潜在风险。