夜间给予外源性褪黑素可能是治疗β受体阻滞剂患者睡眠障碍的一种有效方法。
Night-time exogenous melatonin administration may be a beneficial treatment for sleeping disorders in beta blocker patients.
作者信息
Fares Auda
机构信息
Department of Internal Medicine, S. Johannes Hospital, Germany.
出版信息
J Cardiovasc Dis Res. 2011 Jul;2(3):153-5. doi: 10.4103/0975-3583.85261.
Abstract
Sleep disorders are the common side effects of beta blockers. Beta blockers have been shown to reduce the production of melatonin via specific inhibition of adrenergic beta1-receptors. Exogenous melatonin, taken in the evening as a supplement, could reduce the central nervous system (CNS) side effects (sleep disorder) associated with beta-adrenergic receptor blockers as well as the potential risk associated with reduction of the melatonin synthesis.
摘要
睡眠障碍是β受体阻滞剂常见的副作用。研究表明，β受体阻滞剂可通过特异性抑制肾上腺素能β1受体来减少褪黑素的分泌。作为补充剂在晚上服用外源性褪黑素，可以减轻与β肾上腺素能受体阻滞剂相关的中枢神经系统（CNS）副作用（睡眠障碍）以及与褪黑素合成减少相关的潜在风险。
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