新型 MFS 外排泵 SxtP 由 LysR 型转录激活因子 SxtR 调控，与磺胺甲噁唑/甲氧苄啶（SXT）的易感性和 的发病机制有关。
The novel MFS efflux pump SxtP, regulated by the LysR-type transcriptional activator SxtR, is involved in the susceptibility to sulfamethoxazole/trimethoprim (SXT) and the pathogenesis of .
机构信息
Departament de Genètica i de Microbiologia, Facultat de Biociènces, Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallès (Barcelona), Spain.
出版信息
Antimicrob Agents Chemother. 2024 Oct 8;68(10):e0071224. doi: 10.1128/aac.00712-24. Epub 2024 Aug 28.
Abstract
is a notorious opportunistic pathogen responsible for healthcare-associated infections worldwide. Efflux pumps play crucial roles in mediating antimicrobial resistance, motility, and virulence. In this study, we present the identification and characterization of the new efflux pump SxtP belonging to the MFS superfamily (ajor acilitator uperfamily), along with its associated activator ysRtype ranscriptional egulator (LTTR) SxtR, demonstrating their roles in sulfamethoxazole/trimethoprim (also known as co-trimoxazole or SXT) resistance, surface-associated motility and virulence.
摘要
是一种臭名昭著的机会性病原体，可导致全球范围内的医疗保健相关感染。外排泵在介导抗菌药物耐药性、运动性和毒力方面发挥着关键作用。在这项研究中，我们鉴定并描述了属于 MFS 超家族（主要促进因子超家族）的新型外排泵 SxtP 及其相关激活子 ysR 型转录调节因子（LTTR）SxtR，证明了它们在磺胺甲噁唑/甲氧苄啶（也称为复方新诺明或 SXT）耐药性、表面相关运动性和毒力方面的作用。
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