Kelényi G
Virchows Arch A Pathol Anat Histopathol. 1985;405(3):365-78. doi: 10.1007/BF00710071.
The presence of J or joining chains has been studied in formol-paraffin tissue sections from various lymphoproliferative diseases. The percentages of J chain positivity in 56 cases of multiple myeloma, in 41 of immunocytic malignant lymphoma and 35 of immunoblastic malignant lymphoma were 58.9, 70.7 and 37.1%, respectively. The ratio of kappa to lambda chain types of the monotypic Ig-s was the lowest in multiple myeloma, intermediate in immunocytic and highest in immunoblastic malignant lymphoma (ml). In 8 cases (one local immature plasmocytoma, one non-secretory multiple myeloma, one immunocytic, 4 immunoblastic and one centroblastic malignant lymphoma), only J chains were present in the tumour cells--"J chain disease". A significant difference in survival of J chain positive (26.8 months) and negative (17.7 months) multiple myeloma cases was observed. Myeloma kidney lesions were slightly more frequent in J chain negative cases. In lymphoproliferative disease J chain seems to be associated with early events of Ig synthesis. On the other hand, in two cases with biclonal Ig-s, the IgM positive immunoblastic ml cells and inclusions and the IgA positive multiple myeloma cells and inclusions were J chain positive. The IgG positive cells in both tumours and the IgG positive inclusions in the immunoblastic tumour were negative for J chains.
已对各种淋巴增生性疾病的甲醛 - 石蜡组织切片中J链或连接链的存在情况进行了研究。56例多发性骨髓瘤、41例免疫细胞性恶性淋巴瘤和35例免疫母细胞性恶性淋巴瘤中J链阳性的百分比分别为58.9%、70.7%和37.1%。单型免疫球蛋白的κ链与λ链类型之比在多发性骨髓瘤中最低，在免疫细胞性淋巴瘤中居中，在免疫母细胞性恶性淋巴瘤中最高。在8例病例（1例局部未成熟浆细胞瘤、1例非分泌性多发性骨髓瘤、1例免疫细胞性、4例免疫母细胞性和1例中心母细胞性恶性淋巴瘤）中，肿瘤细胞中仅存在J链——“J链病”。观察到J链阳性（26.8个月）和阴性（17.7个月）的多发性骨髓瘤病例在生存期上存在显著差异。J链阴性病例中骨髓瘤肾病病变略为常见。在淋巴增生性疾病中，J链似乎与免疫球蛋白合成的早期事件有关。另一方面，在2例双克隆免疫球蛋白病例中，IgM阳性的免疫母细胞性恶性淋巴瘤细胞及包涵体和IgA阳性的多发性骨髓瘤细胞及包涵体J链呈阳性。两种肿瘤中的IgG阳性细胞以及免疫母细胞性肿瘤中的IgG阳性包涵体J链均为阴性。
