Wutke K, Várbíró M, Rüdiger K D, Kelényi G
Haematologia (Budap). 1981;14(3):315-29.
In a retrospective study of 202 cases of multiple myeloma (MM) were studied cyto- and histomorphologically. In 62 cases only bone marrow smears, in 60 only histological preparations and in 80 both types of material were available. According to the differentiation of myeloma cells, a plasmocytic (n = 127), a mixed cellular (n = 35) and a plasmoblastic type (n = 32) could be distinguished. Besides, 8 cases with predominance of giant cells were found (giant cell MM). The comparative cytological and histological typing into the four types of MM proved to be reproducible. The medium survival time and survival curves of the described types showed a statistically significant difference. The survival times were 39.7 months with the plasmocytic type, 16.1 months with the mixed cellular type, and 9.8 months with the plasmoblastic type. The prognostic relevance of the morphological classification was supported by the frequency of extramedullary infiltrates (20% in the plasmocytic, 67% in the mixed cell, 69% in the plasmoblastic and 100% in the giant cell type).
对202例多发性骨髓瘤（MM）患者进行了回顾性研究，对其细胞形态学和组织形态学进行了分析。其中62例仅有骨髓涂片，60例仅有组织学标本，80例同时有两种材料。根据骨髓瘤细胞的分化情况，可分为浆细胞型（n = 127）、混合细胞型（n = 35）和成浆细胞型（n = 32）。此外，还发现8例以巨细胞为主的病例（巨细胞MM）。将MM分为上述四种类型的细胞学和组织学比较分型具有可重复性。所描述类型的中位生存时间和生存曲线显示出统计学上的显著差异。浆细胞型的生存时间为39.7个月，混合细胞型为16.1个月，成浆细胞型为9.8个月。髓外浸润的频率支持了形态学分类的预后相关性（浆细胞型为20%，混合细胞型为67%，成浆细胞型为69%，巨细胞型为100%）。
