Laurent G, Delsol G, Reyes F, Abbal M, Mihaesco E
Clin Exp Immunol. 1981 Jun;44(3):620-8.
Lymph node specimens from 125 patients with malignant lymphomas and related disorders were studied by immunoperoxidase procedure for the presence of intracytoplasmic immunoglobulin (CIg) and J chain CIg staining was present in 22/24 cases of lymphoplasmacytic-lymphoplasmacytoid lymphomas, and in 10/10 cases of extramedullary plasmacytomas and myelomas. In the majority of these cases J chain could be demonstrated in plasmacytoid or neoplastic plasma cells. In 21/36 cases of immunoblastic lymphomas, intracytoplasmic Ig staining was present. In only two of the 36 cases were the lymphomatous cells stained positively for J chain. J chain was not detected in other lymphomas such as lymphocytic lymphomas, follicular lymphomas, lymphoblastic lymphomas or in Reed-Sternberg cells or hairy cells. J chain was demonstrated in mature plasma cells and immunoblastic cells in hyperplastic lymph nodes, and in angioimmunoblastic lymphadenopathy. These findings show that J chain is not detectable in all B cell lymphomas even in the presence of CIg synthesis, irrespective of class.
采用免疫过氧化物酶法对125例恶性淋巴瘤及相关疾病患者的淋巴结标本进行研究，以检测胞质内免疫球蛋白（CIg）和J链的存在情况。在22/24例淋巴浆细胞 - 淋巴浆细胞样淋巴瘤、10/10例髓外浆细胞瘤和骨髓瘤中存在CIg染色。在这些病例的大多数中，J链可在浆细胞样或肿瘤性浆细胞中显示。在21/36例免疫母细胞性淋巴瘤中存在胞质内Ig染色。在36例病例中只有2例淋巴瘤细胞J链染色呈阳性。在其他淋巴瘤如淋巴细胞性淋巴瘤、滤泡性淋巴瘤、淋巴母细胞性淋巴瘤中，或在里德 - 斯腾伯格细胞或毛细胞中未检测到J链。在增生性淋巴结的成熟浆细胞和免疫母细胞以及血管免疫母细胞性淋巴结病中显示有J链。这些发现表明，即使存在CIg合成，无论其类别如何，并非所有B细胞淋巴瘤中都能检测到J链。
