School of Pharmacy, Yantai University, Yantai 264005, China.
Yantai Key Laboratory of Characteristic Agricultural Bioresource Conservation & Germplasm Innovative Utilization, School of life sciences, Yantai University, Yantai 264005, China.
Mar Drugs. 2024 Jul 28;22(8):347. doi: 10.3390/md22080347.
Currently, there is an urgent need for new antibacterial and antifungal agents to combat the growing challenge of antibiotic resistance. As the largest ecosystem on Earth, the marine ecosystem includes a vast array of microorganisms (primarily bacteria and fungi), plants, invertebrates, and vertebrates, making it a rich source of various antimicrobial compounds. Notably, terpenoids, known for their complex structures and diverse bioactivities, are a significant and promising group of compounds in the battle against bacterial and fungal infections. In the past five years, numerous antimicrobial terpenoids have been identified from marine organisms such as bacteria, fungi, algae, corals, sea cucumbers, and sponges. This review article provides a detailed overview of 141 terpenoids with antibacterial and/or antifungal properties derived from marine organisms between 2019 and 2024. Terpenoids, a diverse group of natural organic compounds derived from isoprene units, are systematically categorized based on their carbon skeleton structures. Comprehensive information is provided about their names, structures, biological sources, and the extent of their antibacterial and/or antifungal effectiveness. This review aims to facilitate the rapid identification and development of prospective antimicrobials in the pharmaceutical sector.
目前，迫切需要新的抗菌和抗真菌药物来应对抗生素耐药性日益增长的挑战。海洋生态系统是地球上最大的生态系统，其中包含了大量的微生物（主要是细菌和真菌）、植物、无脊椎动物和脊椎动物，是各种抗菌化合物的丰富来源。值得注意的是，萜类化合物以其复杂的结构和多样的生物活性而闻名，是对抗细菌和真菌感染的一类重要且有前途的化合物。在过去的五年中，已经从海洋生物（如细菌、真菌、藻类、珊瑚、海参和海绵）中鉴定出了许多具有抗菌和/或抗真菌特性的萜类化合物。本文综述了 2019 年至 2024 年间从海洋生物中分离得到的 141 种具有抗菌和/或抗真菌活性的萜类化合物。萜类化合物是一类源自异戊二烯单元的天然有机化合物，根据其碳骨架结构进行系统分类。本文详细介绍了它们的名称、结构、生物来源以及在抗菌和/或抗真菌方面的效果。本综述旨在为药物研发领域快速鉴定和开发有前景的抗菌药物提供便利。
