Zupo Roberta, Castellana Fabio, Lisco Giuseppe, Corbo Filomena, Crupi Pasquale, Sardone Rodolfo, Panza Francesco, Lozupone Madia, Rondanelli Mariangela, Clodoveo Maria Lisa
Department of Interdisciplinary Medicine (DIM), University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70100 Bari, Italy.
Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy.
Metabolites. 2024 Jul 25;14(8):404. doi: 10.3390/metabo14080404.
Polyphenols are secondary metabolites found in plants, foods, and drinks, occurring in small quantities and showcasing antioxidant and anti-inflammatory qualities. The primary polyphenols consist of flavonoids, phenolic acids, stilbenes, and lignans. However, there is currently no comprehensive quantitative analysis of epidemiological data on overall death rates. This systematic review with meta-analysis aims to identify the exposure-response relationship between dietary polyphenol intake and all-cause mortality. The literature was reviewed from its earliest study to May 2024, utilizing six distinct electronic databases. No specific criteria were used to choose participants based on the recruiting environment, their general health condition, country, or ethnicity. The inclusion criteria for studies were as follows: a longitudinal design, exposure to dietary polyphenols, all-cause mortality as the outcome, and hazard risk (HR) as the impact measure. The Newcastle-Ottawa Scale was used to evaluate the methodological rigor of the study. The hazard risks (HRs) and 95% confidence intervals (CIs) were estimated by pooling data using common effects models. A protocol has been registered on PROSPERO with the identification number CRD42024545524. The meta-analysis comprised seven cohort studies that involved 178,657 adult people aged 18 years and older. These studies examined the relationship between total dietary polyphenol consumption and the risk of all-cause death. The recruitment settings exclusively used community-based approaches, with a preference for Europe (71%) in terms of geographic distribution. The study's quality was assessed to be moderate to high. The meta-analysis showed consistent evidence that increased dietary exposure to polyphenols reduces the risk of all-cause mortality by 7% (HR 0.93, 95% CI 0.91-0.95, : 48%). Pooled data from the available evidence consistently show that individuals exposed to an antioxidant diet rich in polyphenol sources may be at lower risk of all-cause mortality.
多酚是存在于植物、食物和饮品中的次生代谢产物，含量较少，但具有抗氧化和抗炎特性。主要的多酚包括黄酮类化合物、酚酸、芪类和木脂素。然而，目前尚无关于总体死亡率的流行病学数据的全面定量分析。这项荟萃分析的系统评价旨在确定膳食多酚摄入量与全因死亡率之间的暴露-反应关系。从最早的研究到2024年5月对文献进行了回顾，利用了六个不同的电子数据库。没有根据招募环境、总体健康状况、国家或种族使用特定标准来选择参与者。纳入研究的标准如下：纵向设计、膳食多酚暴露、全因死亡率作为结局以及风险比（HR）作为影响指标。使用纽卡斯尔-渥太华量表评估研究的方法严谨性。通过使用共同效应模型汇总数据来估计风险比（HRs）和95%置信区间（CIs）。一项方案已在PROSPERO上注册，识别号为CRD42024545524。荟萃分析包括七项队列研究，涉及178,657名18岁及以上的成年人。这些研究考察了膳食多酚总摄入量与全因死亡风险之间的关系。招募设置仅采用基于社区的方法，就地理分布而言，欧洲占比最高（71%）。研究质量评估为中等至高。荟萃分析显示了一致的证据，即增加膳食中多酚的摄入量可使全因死亡率风险降低7%（HR 0.93，95% CI 0.91-0.95，I²：48%）。现有证据的汇总数据一致表明，摄入富含多酚来源的抗氧化饮食的个体全因死亡率风险可能较低。
