Hoagland P M, Cook E F, Flatley M, Walker C, Goldman L
Am J Cardiol. 1985 Mar 1;55(6):744-7. doi: 10.1016/0002-9149(85)90149-3.
To analyze whether atherosclerotic risk factors, including systemic hypertension, an elevated serum cholesterol level, smoking and diabetes, were associated with the presence of aortic stenosis (AS) in adults, 105 adults who had AS without coronary artery disease (CAD) were compared with 110 control subjects who had other types of valvular disease, 170 control subjects who underwent catheterization and had neither valvular disease nor CAD, and 269 matched control subjects who underwent general surgery. When using each control group separately or in combination, no risk factor showed consistent evidence of a significant association with the development of AS. If the true magnitudes of these associations are of the order previously reported for the development of CAD, the power of our study for detecting statistical significance ranges from 56 to 99%. In a supplemental analysis, 45 cases with both AS and CAD did not have a higher prevalence of risk factors than cases without CAD. Although a weak association between atherosclerotic risk factors and AS cannot be excluded, any such association is unlikely to be as strong as for predicting CAD.
为分析包括系统性高血压、血清胆固醇水平升高、吸烟和糖尿病在内的动脉粥样硬化风险因素是否与成人主动脉瓣狭窄（AS）的存在相关，将105例患有AS但无冠状动脉疾病（CAD）的成人与110例患有其他类型瓣膜疾病的对照受试者、170例接受导管插入术且既无瓣膜疾病也无CAD的对照受试者以及269例接受普通外科手术的匹配对照受试者进行了比较。当分别或联合使用每个对照组时，没有风险因素显示出与AS发生存在显著关联的一致证据。如果这些关联的真实强度与先前报道的CAD发生的强度相当，我们研究检测统计学显著性的效能范围为56%至99%。在一项补充分析中，45例同时患有AS和CAD的病例的风险因素患病率并不高于无CAD的病例。虽然不能排除动脉粥样硬化风险因素与AS之间存在弱关联，但任何此类关联不太可能像预测CAD那样强。
