Giancola Maria Letizia, Haggiag Shalom, Corpolongo Angela, Stasolla Alessandro, Mariano Andrea, Menniti Agazio, Campioni Paolo, Bartolini Barbara, Galizia Pierluigi, Vulcano Antonella, Fontana Carla, Gasperini Claudio, O'Connell Elise, Garcia Hector H, Nash Theodore E, Nicastri Emanuele
Clinical Department, National Institute for Infectious Diseases "Lazzaro Spallanzani", Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy.
Department of Neuroscience, Azienda Ospedaliera San Camillo Forlanini, 00152 Rome, Italy.
Trop Med Infect Dis. 2024 Aug 21;9(8):187. doi: 10.3390/tropicalmed9080187.
Neurocysticercosis (NCC) is caused by the larval stage of . This parasitic disease is endemic in many areas of the world and is emerging in Europe. NCC can affect different brain regions, but simultaneous involvement of the parenchymal, subarachnoid, and ventricular regions is rare. We report the case of a 39-year-old woman from Honduras, resident in Rome for 10 years, who presented to the Emergency Department complaining of headaches, transient hemianopsia, and bilateral papilledema. MRI showed a concomitant parenchymal, subarachnoid, and ventricular involvement in the brain. IgG antibodies were detected in the blood. The etiological diagnosis of NCC was obtained by identifying in cerebrospinal fluid using Next Generation Sequencing. Endoscopic neurosurgery with the placement of a ventricular shunt and medical long-term anti-parasitic treatment with a cumulative number of 463 days of albendazole and 80 days of praziquantel were performed. A successful 4-year follow-up is reported. NCC is one of the most common parasitic infections of the human CNS, but it is still a neglected tropical disease and is considered to be an emerging disease in Europe. Its diagnosis and clinical management remain a challenge, especially for European clinicians.
神经囊尾蚴病（NCC）由[某种寄生虫]的幼虫阶段引起。这种寄生虫病在世界许多地区呈地方性流行，在欧洲也有出现。NCC可累及不同脑区，但脑实质、蛛网膜下腔和脑室区域同时受累的情况罕见。我们报告一例39岁来自洪都拉斯的女性病例，她在罗马居住了10年，因头痛、短暂性偏盲和双侧视乳头水肿就诊于急诊科。磁共振成像（MRI）显示脑部脑实质、蛛网膜下腔和脑室同时受累。血液中检测到IgG抗体。通过下一代测序在脑脊液中鉴定出[某种病原体]从而获得NCC的病因诊断。实施了内镜神经外科手术并放置脑室分流管，以及累计463天的阿苯达唑和80天的吡喹酮长期抗寄生虫药物治疗。报告了4年的成功随访情况。NCC是人类中枢神经系统最常见的寄生虫感染之一，但它仍然是一种被忽视的热带病，在欧洲被视为一种新兴疾病。其诊断和临床管理仍然是一项挑战，尤其对于欧洲的临床医生而言。
