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功能性髋关节发育不良兔模型中髋关节的形态测量评估

Morphometric Assessment of the Hip Joint in a Functional Dysplastic Rabbit Model.

作者信息

Tomé Inês, Costa Luís, Alves-Pimenta Sofia, Sargo Roberto, Pereira José, Colaço Bruno, Ginja Mário

机构信息

Veterinary Teaching Hospital, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal.

Associate Laboratory for Animal and Veterinary Science (AL4AnimalS), CECAV-Veterinary and Animal Science Research Centre, University of Trás-os-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal.

出版信息

Vet Sci. 2024 Aug 22;11(8):387. doi: 10.3390/vetsci11080387.

DOI:10.3390/vetsci11080387
PMID:39195841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11359858/
Abstract

The present study investigates the morphometric changes in the hip joint in a surgically induced rabbit model of hip dysplasia through the sectioning of the ligamentum capitis femoris and pelvic limb immobilization. A total of seventeen rabbits were evaluated using radiographic and computed tomographic imaging to measure the following parameters: the femoral angles of anteversion and inclination, length and width indexes of the neck of the femur, and acetabular depth and ventroversion. Significant differences in femoral anteversion angle and acetabular depth were observed, particularly in the group of hip instability surgery with pelvic limb immobilization. The results have shown the influence of hip joint instability in the promotion of femoral anteversion and acetabular shallowing. These findings provide a foundation for future research on naturally occurring or experimentally induced hip dysplasia in rabbits and underscore the model's potential for studying the biomechanical and developmental aspects of hip joint disorders.

摘要

本研究通过切断股骨头韧带和固定后肢,在手术诱导的兔髋关节发育不良模型中研究髋关节的形态学变化。使用放射成像和计算机断层扫描成像对总共17只兔子进行评估,以测量以下参数:股骨前倾角和倾斜角、股骨颈的长度和宽度指数以及髋臼深度和前倾角。观察到股骨前倾角和髋臼深度存在显著差异,特别是在伴有后肢固定的髋关节不稳定手术组中。结果表明髋关节不稳定对股骨前倾角增加和髋臼变浅有影响。这些发现为未来研究兔子自然发生或实验诱导的髋关节发育不良奠定了基础,并强调了该模型在研究髋关节疾病的生物力学和发育方面的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c334/11359858/280b0871c86f/vetsci-11-00387-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c334/11359858/5377a7f4c9d6/vetsci-11-00387-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c334/11359858/daa4dd57962f/vetsci-11-00387-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c334/11359858/5f62ccf88ae4/vetsci-11-00387-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c334/11359858/280b0871c86f/vetsci-11-00387-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c334/11359858/5377a7f4c9d6/vetsci-11-00387-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c334/11359858/daa4dd57962f/vetsci-11-00387-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c334/11359858/5f62ccf88ae4/vetsci-11-00387-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c334/11359858/280b0871c86f/vetsci-11-00387-g004.jpg

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Front Pediatr. 2023 Oct 16;11:1247455. doi: 10.3389/fped.2023.1247455. eCollection 2023.
2
Mechanical osteoarthritis of the hip in a one medicine concept: a narrative review.一医学理念中的髋关节机械性骨关节炎:叙述性综述。
BMC Vet Res. 2023 Oct 24;19(1):222. doi: 10.1186/s12917-023-03777-z.
3
Establishment of an ultrasound-guided protocol for the assessment of hip joint osteoarthritis in rabbits-A sonoanatomic study.
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PLoS One. 2023 Sep 14;18(9):e0291177. doi: 10.1371/journal.pone.0291177. eCollection 2023.
4
Rabbit hindlimb kinematics and ground contact kinetics during the stance phase of gait.兔后肢运动学和步态支撑相的地面接触动力学。
PeerJ. 2022 Jun 17;10:e13611. doi: 10.7717/peerj.13611. eCollection 2022.
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THE ROUND LIGAMENT IN DEVELOPMENTAL HIP DYSPLASIA: ARE ITS MECHANICAL AND HISTOLOGICAL PROPERTIES PRESERVED?发育性髋关节发育不良中的圆韧带:其力学和组织学特性是否得以保留?
Acta Ortop Bras. 2022 Jan 28;30(1):e235808. doi: 10.1590/1413-785220223001e235808. eCollection 2022.
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J Anat. 2020 Nov;237(5):811-826. doi: 10.1111/joa.13249. Epub 2020 Jun 24.
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