Howat A J, Variend S
Am J Surg Pathol. 1985 Feb;9(2):125-8. doi: 10.1097/00000478-198502000-00007.
Forty-nine Spitz nevi occurring in children were reviewed and sampled extensively in order to assess the incidence of vascular invasion. Evidence of vascular invasion was found in seven (14.3%) cases. The endothelium of such vessels was negative on immunoperoxidase staining for Factor VIII-related antigen suggesting the nevus cells to be in lymphatic channels and not blood vessels. No unusual histological or clinical features characterized the group. All patients are alive and well some years after local excision therapy. It is concluded that lymphatic invasion by nevus cells in Spitz nevi is not uncommon and its presence should not tempt the pathologist into a diagnosis of melanoma.
对49例发生于儿童的斯皮茨痣进行了回顾性研究，并进行了广泛取样，以评估血管侵犯的发生率。在7例（14.3%）病例中发现了血管侵犯的证据。此类血管的内皮细胞在免疫过氧化物酶染色中对VIII因子相关抗原呈阴性，提示痣细胞位于淋巴管而非血管内。该组病例无特殊的组织学或临床特征。所有患者在局部切除治疗数年后均存活且状况良好。结论是，斯皮茨痣中痣细胞的淋巴管侵犯并不罕见，其存在不应诱使病理学家诊断为黑色素瘤。
