Modlin R L, Gottlieb B, Taylor C, Rea T H
Am J Dermatopathol. 1984 Summer;6 Suppl:25-9.
So-called pseudovascular spaces, said to occur in 10% of benign pigmented nevi, are presumed to be shrinkage artifacts of tissue processing. In an attempt to characterize the cells lining these spaces, three benign pigmented nevi were studied with immunoperoxidase techniques. It was found that they stained positively with an anti-melanoma antibody, P97a (gamma-2a), but negatively with an antibody against an antigen-related factor VIII, which is a marker for vascular endothelium. We conclude that these spaces are lined by melanocytes of nevi and that the spaces are not truly vascular. In one specimen, the spaces were filled with erythrocytes, which suggest that the spaces were present before fixation. It has been suggested, though, that altered collagen and elastic tissue and the nevi themselves may diminish the resistance of the dermis to the mechanical stress of the biopsy procedure, which results in the formation of these spaces.
所谓的假血管腔隙据说在10%的良性色素痣中出现，被认为是组织处理过程中的收缩假象。为了对衬于这些腔隙的细胞进行特征描述，采用免疫过氧化物酶技术对3例良性色素痣进行了研究。发现它们用抗黑色素瘤抗体P97a（γ-2a）染色呈阳性，但用抗血管内皮标记物抗原相关因子VIII的抗体染色呈阴性。我们得出结论，这些腔隙由痣的黑素细胞衬里，且这些腔隙并非真正的血管。在1个标本中，腔隙内充满红细胞，这表明这些腔隙在固定前就已存在。然而，有人提出，改变的胶原和弹性组织以及痣本身可能会降低真皮对活检操作机械应力的抵抗力，从而导致这些腔隙的形成。
