Diephuis J C, Sprinkhuizen J Q, Van der Haven A, Noorduin H, Booij L H
Slotervaart Hospital, Amsterdam, The Netherlands.
Pharm Weekbl Sci. 1988 Jun 17;10(3):117-21. doi: 10.1007/BF01959295.
A comparison of alfentanil and fentanyl was made with special reference to their postoperative effects. The study was performed double-blind in one hundred patients of either sex, undergoing elective surgery for hernia nuclei pulposi. All patients received thiopental, pancuronium, droperidol and 1-2 ml of a randomly selected ampoule, containing either 0.5 mg per ml alfentanil or 0.05 mg per ml fentanyl, for induction of anaesthesia. After positioning the patient, a 3-4 ml bolus dose of the analgesic was administered and occasional increments were given thereafter. There were significantly fewer responses to intubation in the 'alfentanil patients' than in the 'fentanyl patients'. Extubation time, although of little clinical importance, was significantly shorter in the alfentanil group. 12 Patients who were treated with alfentanil and 10 patients who were treated with fentanyl required the administration of an analgesic after mean time intervals of 65 and 64 min, respectively. Recovery of consciousness was similar in the two groups, but alertness 45 min after completion of the operation was significantly better in the alfentanil group: 52% were fully awake, as compared with 30% after administration of fentanyl.
对阿芬太尼和芬太尼进行了比较，特别关注它们的术后效果。该研究在100例择期进行髓核突出症手术的患者中进行，患者性别不限，采用双盲法。所有患者均接受硫喷妥钠、泮库溴铵、氟哌利多，并随机抽取1 - 2毫升安瓿瓶药物用于麻醉诱导，安瓿瓶中所含药物为每毫升含0.5毫克阿芬太尼或每毫升含0.05毫克芬太尼。患者体位安置好后，给予3 - 4毫升镇痛药物推注剂量，随后视情况偶尔追加剂量。“阿芬太尼组患者”对插管的反应明显少于“芬太尼组患者”。拔管时间虽临床意义不大，但阿芬太尼组明显更短。接受阿芬太尼治疗的12例患者和接受芬太尼治疗的10例患者分别在平均65分钟和64分钟的时间间隔后需要给予镇痛药。两组患者意识恢复情况相似，但术后45分钟时阿芬太尼组的警觉性明显更好：52%的患者完全清醒，而使用芬太尼后这一比例为30%。
