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Targeting metabolically activated fibroblasts in the failing heart.

作者信息

Frangogiannis Nikolaos G

机构信息

The Wilf Family Cardiovascular Research Institute, Department of Medicine (Cardiology), Albert Einstein College of Medicine, New York City, NY, USA.

出版信息

Nat Cardiovasc Res. 2024 Jul;3(7):782-784. doi: 10.1038/s44161-024-00500-5.

DOI:10.1038/s44161-024-00500-5
PMID:39196174
Abstract
摘要

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1
Targeting metabolically activated fibroblasts in the failing heart.靶向衰竭心脏中代谢活化的成纤维细胞。
Nat Cardiovasc Res. 2024 Jul;3(7):782-784. doi: 10.1038/s44161-024-00500-5.
2
Cardiac fibroblasts: from development to heart failure.心脏成纤维细胞:从发育到心力衰竭
J Mol Med (Berl). 2015 Aug;93(8):823-30. doi: 10.1007/s00109-015-1314-y. Epub 2015 Jul 14.
3
Getting energy to where it is required is a problem in the failing heart.将能量输送到所需部位是衰竭心脏面临的一个问题。
J Physiol. 2008 Nov 1;586(21):5037-8. doi: 10.1113/jphysiol.2008.163246.
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Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation.内质网蛋白 TXNDC5 通过促进细胞外基质蛋白折叠和氧化还原敏感的心肌成纤维细胞激活来增强心肌纤维化。
Circ Res. 2018 Apr 13;122(8):1052-1068. doi: 10.1161/CIRCRESAHA.117.312130. Epub 2018 Mar 13.
5
Introduction to special issue on myocardial energy metabolism in heart failure.
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6
Deranged energy substrate metabolism in the failing heart.衰竭心脏中能量底物代谢紊乱。
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7
The failing heart.
N Engl J Med. 2007 Jun 14;356(24):2546; author reply 2546.
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The Failing Heart: Energy Supply, Processing, and Transfer.衰竭心脏:能量供应、处理与传递
Methodist Debakey Cardiovasc J. 2017 Jan-Mar;13(1):3. doi: 10.14797/mdcj-13-1-3.
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Is the failing heart energy depleted?衰竭的心脏是否能量耗尽?
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10
The failing heart.
N Engl J Med. 2007 Jun 14;356(24):2545-6; author reply 2546.

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Deciphering myocardial fibrosis: a comprehensive bibliometric analysis of mechanism over the period 1992-2023.解读心肌纤维化:1992 - 2023年期间机制的全面文献计量分析
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Lethal Arrhythmogenic Role of Left Ventricular Myocardial Interstitial Fibrosis in Apolipoprotein E/Low-Density Lipoprotein Receptor Double-Knockout Mice with Metabolic Dysfunction-Associated Steatohepatitis.左心室心肌间质纤维化在载脂蛋白E/低密度脂蛋白受体双敲除且伴有代谢功能障碍相关脂肪性肝炎小鼠中的致死性致心律失常作用
Int J Mol Sci. 2024 Dec 27;26(1):144. doi: 10.3390/ijms26010144.

本文引用的文献

1
Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis.作者更正:正常组织修复和纤维化过程中的成纤维细胞及肌成纤维细胞激活
Nat Rev Mol Cell Biol. 2024 Aug;25(8):671. doi: 10.1038/s41580-024-00744-w.
2
Loss of Acta2 in cardiac fibroblasts does not prevent the myofibroblast differentiation or affect the cardiac repair after myocardial infarction.心肌梗死后,心脏成纤维细胞中 Acta2 的缺失既不会阻止肌成纤维细胞的分化,也不会影响心脏修复。
J Mol Cell Cardiol. 2022 Oct;171:117-132. doi: 10.1016/j.yjmcc.2022.08.003. Epub 2022 Aug 22.
3
Smad7 effects on TGF-β and ErbB2 restrain myofibroblast activation and protect from postinfarction heart failure.
Smad7 通过抑制 TGF-β 和 ErbB2 抑制成肌纤维细胞激活,从而预防心肌梗死后心力衰竭。
J Clin Invest. 2022 Feb 1;132(3). doi: 10.1172/JCI146926.
4
High-Resolution Transcriptomic Profiling of the Heart During Chronic Stress Reveals Cellular Drivers of Cardiac Fibrosis and Hypertrophy.慢性应激过程中心脏的高分辨率转录组特征分析揭示了心脏纤维化和肥大的细胞驱动因素。
Circulation. 2020 Oct 13;142(15):1448-1463. doi: 10.1161/CIRCULATIONAHA.119.045115. Epub 2020 Jul 30.
5
Myofibroblasts and Fibrosis: Mitochondrial and Metabolic Control of Cellular Differentiation.肌成纤维细胞与纤维化:细胞分化的线粒体与代谢调控
Circ Res. 2020 Jul 17;127(3):427-447. doi: 10.1161/CIRCRESAHA.120.316958. Epub 2020 Jul 16.
6
Cardiac Fibroblast Diversity.心肌成纤维细胞多样性。
Annu Rev Physiol. 2020 Feb 10;82:63-78. doi: 10.1146/annurev-physiol-021119-034527.
7
Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation.线粒体钙交换将代谢与表观基因组联系起来,以控制细胞分化。
Nat Commun. 2019 Oct 4;10(1):4509. doi: 10.1038/s41467-019-12103-x.
8
Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart.特化的成纤维细胞分化状态是导致梗死小鼠心脏形成瘢痕的基础。
J Clin Invest. 2018 May 1;128(5):2127-2143. doi: 10.1172/JCI98215. Epub 2018 Apr 16.
9
Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells.糖酵解介导的乙酰辅酶 A 变化和组蛋白乙酰化控制胚胎干细胞的早期分化。
Cell Metab. 2015 Mar 3;21(3):392-402. doi: 10.1016/j.cmet.2015.02.002.