Tan Wilson Lek Wen, Seow Wei Qiang, Zhang Angela, Rhee Siyeon, Wong Wing H, Greenleaf William J, Wu Joseph C
Stanford Cardiovascular Institute, Stanford, CA, USA.
Greenstone Biosciences, Palo Alto, CA, USA.
Nat Cardiovasc Res. 2023 Jan;2(1):20-34. doi: 10.1038/s44161-022-00205-7. Epub 2023 Jan 18.
Single-cell technology has become an indispensable tool in cardiovascular research since its first introduction in 2009. Here, we highlight the recent remarkable progress in using single-cell technology to study transcriptomic and epigenetic heterogeneity in cardiac disease and development. We then introduce the key concepts in single-cell multi-omics modalities that apply to cardiovascular research. Lastly, we discuss some of the trending concepts in single-cell technology that are expected to propel cardiovascular research to the next phase of single-cell research.
自2009年首次引入以来，单细胞技术已成为心血管研究中不可或缺的工具。在此，我们重点介绍了利用单细胞技术研究心脏病和心脏发育过程中转录组和表观遗传异质性方面最近取得的显著进展。然后，我们介绍了适用于心血管研究的单细胞多组学模式中的关键概念。最后，我们讨论了单细胞技术中的一些热门概念，这些概念有望推动心血管研究进入单细胞研究的下一阶段。
