Claeson Anna-Sara, Rosa Eduardo, Nordin Steven
Department of Psychology, Umeå University, Umeå, Sweden.
Int J Environ Health Res. 2025 Jun;35(6):1515-1524. doi: 10.1080/09603123.2024.2395436. Epub 2024 Aug 28.
Acrolein is considered a risk factor for indoor air health problems due to its reactivity. An objective of the study was to investigate prevalence of sensory irritation in terms of time-dependent detection and perceived intensity of symptoms in human volunteers. Another objective was to investigate individual variation in sensory irritation. Participants (=40) were exposed twice in an exposure chamber (15 min), once to heptane and once to acrolein and heptane. Symptoms and sensory irritation thresholds were rated continuously and 70% of the participants detected eye irritation from the acrolein exposure. A significant interaction between time and exposure (ƞp=0.19) was identified, indicating time-dependent activation. This group also reported a higher level of stress and lower self-reported health (<0.05). The results suggest that the eye is the primary system affected by exposure to acrolein, and that duration of exposure and perceived stress play important roles in symptom reactions due to acrolein exposure.
由于其反应活性，丙烯醛被认为是室内空气健康问题的一个风险因素。该研究的一个目的是根据人类志愿者中症状的时间依赖性检测和感知强度来调查感觉刺激的发生率。另一个目的是调查感觉刺激的个体差异。40名参与者在暴露舱中暴露两次（每次15分钟），一次暴露于庚烷，一次暴露于丙烯醛和庚烷。连续对症状和感觉刺激阈值进行评分，70%的参与者检测到丙烯醛暴露引起的眼部刺激。确定了时间和暴露之间的显著交互作用（ƞp=0.19），表明存在时间依赖性激活。该组还报告了更高水平的压力和更低的自我报告健康状况（<0.05）。结果表明，眼睛是受丙烯醛暴露影响的主要系统，并且暴露持续时间和感知压力在丙烯醛暴露引起的症状反应中起重要作用。
