地塞米松可增加妊娠晚期恒河猴胎儿肝脏中胆红素、雌二醇和睾酮的UDP-葡萄糖醛酸基转移酶活性。
Dexamethasone increases UDP-glucuronyltransferase activity towards bilirubin, oestradiol and testosterone in foetal liver from rhesus monkey during late gestation.
作者信息
Leakey J E, Althaus Z R, Bailey J R, Slikker W
出版信息
Biochem J. 1985 Jan 1;225(1):183-8. doi: 10.1042/bj2250183.
We previously showed that in perinatal rhesus monkeys hepatic UDP-glucuronyltransferase activities appear to develop differentially in two clusters, analogous to those of the rat. We demonstrate here that hepatic UDP-glucuronyltransferase activities differ between the rat and the rhesus monkey in their response to glucocorticoids. Treatment of pregnant rhesus monkeys with dexamethasone during late gestation increases UDP-glucuronyltransferase activities towards bilirubin, oestradiol and testosterone in the foetal-liver microsomal fraction to 25, 4 and 4 times their low control values respectively. Analogous dexamethasone treatment in rat fails to increase these activities significantly in the foetal liver. These findings suggest that maternal glucocorticoid therapy in late gestation could greatly increase the newborn primate's capacity to glucuronidate bilirubin.
我们之前发现，围产期恒河猴肝脏中的尿苷二磷酸葡萄糖醛酸基转移酶（UDP-葡糖醛酸转移酶）活性似乎在两个簇中差异发育，类似于大鼠的情况。我们在此证明，大鼠和恒河猴肝脏中的UDP-葡糖醛酸转移酶活性对糖皮质激素的反应不同。在妊娠晚期用地塞米松治疗怀孕的恒河猴，可使胎儿肝脏微粒体部分中针对胆红素、雌二醇和睾酮的UDP-葡糖醛酸转移酶活性分别增加至其低对照值的25倍、4倍和4倍。在大鼠中进行类似的地塞米松治疗，未能显著增加胎儿肝脏中的这些活性。这些发现表明，妊娠晚期的母体糖皮质激素治疗可大大提高新生灵长类动物对胆红素进行葡糖醛酸化的能力。
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