尿苷二磷酸葡萄糖醛酸基转移酶活性在恒河猴胎儿肝脏中呈现出两个发育组。
UDP-glucuronyltransferase activity exhibits two developmental groups in liver from foetal rhesus monkeys.
作者信息
Leakey J E, Althaus Z R, Bailey J R, Slikker W
出版信息
Biochem J. 1983 Sep 15;214(3):1007-9. doi: 10.1042/bj2141007.
Abstract
UDP-glucuronyltransferase was assayed in liver from adult rhesus monkeys and foetuses during late gestation. Activities toward 2-aminophenol, 5-hydroxytryptamine, 1-naphthol and 4-nitrophenol in the foetal liver ranged from 46 to 114% of adult values, whereas activities toward bilirubin, oestradiol and testosterone were less than 5% of adult values. This suggests that in primates UDP-glucuronyltransferase develops differentially in two clusters analogous to that in the rat.
摘要
在成年恒河猴以及妊娠晚期胎儿的肝脏中对尿苷二磷酸葡萄糖醛酸基转移酶进行了测定。胎儿肝脏中针对2-氨基酚、5-羟色胺、1-萘酚和4-硝基酚的活性为成年值的46%至114%，而针对胆红素、雌二醇和睾酮的活性则低于成年值的5%。这表明在灵长类动物中，尿苷二磷酸葡萄糖醛酸基转移酶在两个类似于大鼠的簇中差异发育。
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引用本文的文献
1
Dexamethasone increases UDP-glucuronyltransferase activity towards bilirubin, oestradiol and testosterone in foetal liver from rhesus monkey during late gestation.地塞米松可增加妊娠晚期恒河猴胎儿肝脏中胆红素、雌二醇和睾酮的UDP-葡萄糖醛酸基转移酶活性。
Biochem J. 1985 Jan 1;225(1):183-8. doi: 10.1042/bj2250183.
2
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Biochem J. 1987 May 1;243(3):859-61. doi: 10.1042/bj2430859.
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Determination of bilirubin glucuronide and assay of glucuronyltransferase with bilirubin as acceptor.胆红素葡萄糖醛酸苷的测定及以胆红素为受体的葡萄糖醛酸转移酶的测定。
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An improved assay for steroid glucuronyltransferase in rat liver microsomes.大鼠肝微粒体中类固醇葡萄糖醛酸转移酶的一种改良测定法。
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Relationship beteen activation of "detoxicating" enzymes in stored broken-cell preparations and in autolysing liver.储存的破碎细胞制剂和自溶肝脏中“解毒”酶的激活之间的关系。
Enzyme. 1975;20(3):156-64. doi: 10.1159/000458934.
8
Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver.人肝脏中尿苷二磷酸葡萄糖醛酸基转移酶对胆红素和2-氨基苯酚活性的产后发育
Biochem J. 1979 Dec 15;184(3):705-7. doi: 10.1042/bj1840705.
9
An improved assay technique for uridine diphosphate glucuronosyltransferase activity towards 5-hydroxytryptamine and some properties of the enzyme.一种针对5-羟色胺的尿苷二磷酸葡萄糖醛酸基转移酶活性的改进测定技术及该酶的一些特性。
Biochem J. 1978 Dec 1;175(3):1119-24. doi: 10.1042/bj1751119.
10
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Biochem J. 1978 Aug 15;174(2):485-9. doi: 10.1042/bj1740485.
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