School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Sishui Siheyuan Culture and Tourism Development Company, Ltd, Sishui 273200, China.
J Pharm Biomed Anal. 2024 Dec 15;251:116442. doi: 10.1016/j.jpba.2024.116442. Epub 2024 Aug 22.
Polygala tenuifolia is a well-known traditional Chinese medicine. Polygala tenuifolia polysaccharide (PTP), as one of its main active ingredients, has excellent neuroprotective activity. PTP improved the disruption of the endogenous metabolites and gut microbiota caused by Alzheimer's disease (AD). Specifically, untargeted metabolomics results showed that 19 metabolites such as leukotriene B4, vanylglycol, and cer(d18:1/18:0) are significantly reduced, and 2 metabolites are elevated. It was significantly enriched in Sphingolipid metabolism, Glycerophospholipid metabolism, Tyrosine metabolism, and Arachidonic acid metabolism. Meanwhile, 16S rDNA analysis showed that PTP treatment significantly increased the relative abundance of bacteria such as Alistipes, Lachnospiraceae_NK4A136_group, and Lachnospiraceae_UCG-006. In addition, Spearman analysis showed that significant changes in gut microbiota were closely related to differential endogenous metabolites.
远志是一种著名的中药。远志多糖（PTP）作为其主要活性成分之一，具有优异的神经保护活性。PTP 改善了阿尔茨海默病（AD）引起的内源性代谢物和肠道微生物群的破坏。具体来说，非靶向代谢组学结果表明，19 种代谢物（如白三烯 B4、vanylglycol 和 cer(d18:1/18:0）显著降低，2 种代谢物升高。它在鞘脂代谢、甘油磷脂代谢、酪氨酸代谢和花生四烯酸代谢中显著富集。同时，16S rDNA 分析表明，PTP 处理显著增加了 Alistipes、Lachnospiraceae_NK4A136_group 和 Lachnospiraceae_UCG-006 等细菌的相对丰度。此外，Spearman 分析表明，肠道微生物群的显著变化与差异内源性代谢物密切相关。
