钙拮抗剂可刺激射出的人类精液中的精子活力。
Calcium antagonists stimulate sperm motility in ejaculated human semen.
作者信息
Hong C Y, Chiang B N, Ku J, Wei Y H, Fong J C
出版信息
Br J Clin Pharmacol. 1985 Jan;19(1):45-9. doi: 10.1111/j.1365-2125.1985.tb02611.x.
Abstract
Three calcium antagonists, diltiazem, flunarizine and verapamil stimulated human sperm motility in vitro. Among them, diltiazem induced the largest amplitude of motility increase. The concentration-response curve of diltiazem was similar in shape to those of calcium chelators. EGTA, a calcium chelator, potentiated the stimulatory effect of diltiazem while A23187, a calcium ionophore, antagonized it. These observations supported our previous hypothesis that an increased concentration of calcium ion was detrimental to human sperm motility. Whether calcium antagonists could be used in the treatment of subfertile patients awaits further investigation.
摘要
三种钙拮抗剂，地尔硫䓬、氟桂利嗪和维拉帕米，在体外刺激了人类精子的活力。其中，地尔硫䓬引起的活力增加幅度最大。地尔硫䓬的浓度-反应曲线形状与钙螯合剂的相似。钙螯合剂乙二醇双四乙酸（EGTA）增强了地尔硫䓬的刺激作用，而钙离子载体A23187则起到拮抗作用。这些观察结果支持了我们之前的假设，即钙离子浓度升高对人类精子活力有害。钙拮抗剂是否可用于治疗不育症患者有待进一步研究。
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