Acquisition parameters influence AI recognition of race in chest x-rays and mitigating these factors reduces underdiagnosis bias.

A core motivation for the use of artificial intelligence (AI) in medicine is to reduce existing healthcare disparities. Yet, recent studies have demonstrated two distinct findings: (1) AI models can show performance biases in underserved populations, and (2) these same models can be directly trained to recognize patient demographics, such as predicting self-reported race from medical images alone. Here, we investigate how these findings may be related, with an end goal of reducing a previously identified underdiagnosis bias. Using two popular chest x-ray datasets, we first demonstrate that technical parameters related to image acquisition and processing influence AI models trained to predict patient race, where these results partly reflect underlying biases in the original clinical datasets. We then find that mitigating the observed differences through a demographics-independent calibration strategy reduces the previously identified bias. While many factors likely contribute to AI bias and demographics prediction, these results highlight the importance of carefully considering data acquisition and processing parameters in AI development and healthcare equity more broadly.