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嵌套神经回路的活动驱动果蝇不同的求爱歌曲。

Activity of nested neural circuits drives different courtship songs in Drosophila.

机构信息

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.

Lingang Laboratory, Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai, China.

出版信息

Nat Neurosci. 2024 Oct;27(10):1954-1965. doi: 10.1038/s41593-024-01738-9. Epub 2024 Aug 28.

DOI:10.1038/s41593-024-01738-9
PMID:39198658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11452343/
Abstract

Motor systems implement diverse motor programs to pattern behavioral sequences, yet how different motor actions are controlled on a moment-by-moment basis remains unclear. Here, we investigated the neural circuit mechanisms underlying the control of distinct courtship songs in Drosophila. Courting males rapidly alternate between two types of song: pulse and sine. By recording calcium signals in the ventral nerve cord in singing flies, we found that one neural population is active during both songs, whereas an expanded neural population, which includes neurons from the first population, is active during pulse song. Brain recordings showed that this nested activation pattern is present in two descending pathways required for singing. Connectomic analysis reveals that these two descending pathways provide structured input to ventral nerve cord neurons in a manner consistent with their activation patterns. These results suggest that nested premotor circuit activity, directed by distinct descending signals, enables rapid switching between motor actions.

摘要

运动系统执行多样化的运动程序来形成行为序列，但不同的运动动作如何在瞬间得到控制仍不清楚。在这里，我们研究了果蝇求偶歌曲控制的神经回路机制。求偶的雄性会快速地在两种类型的歌曲之间切换：脉冲声和正弦声。通过在唱歌的果蝇的腹神经索中记录钙信号，我们发现一个神经群体在两种歌曲中都活跃，而一个扩展的神经群体，包括来自第一个群体的神经元，在脉冲声中活跃。大脑记录显示，这种嵌套的激活模式存在于两个用于唱歌的下行途径中。连接组学分析表明，这两个下行途径以与它们的激活模式一致的方式，为腹神经索神经元提供结构化的输入。这些结果表明，由不同的下行信号指导的嵌套运动前回路活动，使得运动动作之间的快速切换成为可能。

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